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dc.contributor.authorDe Ruysscher, D
dc.contributor.authorNiedermann, G
dc.contributor.authorBurnet, Neil G
dc.contributor.authorSiva, S
dc.contributor.authorLee, M
dc.contributor.authorHegi-Johnson, F
dc.date.accessioned2019-03-29T14:22:35Z
dc.date.available2019-03-29T14:22:35Z
dc.date.issued2019en
dc.identifier.citationDe Ruysscher D, Niedermann G, Burnet N, Siva S, Lee A, Hegi-Johnson F. Radiotherapy toxicity. Nat Rev Dis Primers. 2019;5(1):13.en
dc.identifier.pmid30792503en
dc.identifier.doi10.1038/s41572-019-0064-5en
dc.identifier.urihttp://hdl.handle.net/10541/621702
dc.description.abstractRadiotherapy is used in >50% of patients with cancer, both for curative and palliative purposes. Radiotherapy uses ionizing radiation to target and kill tumour tissue, but normal tissue can also be damaged, leading to toxicity. Modern and precise radiotherapy techniques, such as intensity-modulated radiotherapy, may prevent toxicity, but some patients still experience adverse effects. The physiopathology of toxicity is dependent on many parameters, such as the location of irradiation or the functional status of organs at risk. Knowledge of the mechanisms leads to a more rational approach for controlling radiotherapy toxicity, which may result in improved symptom control and quality of life for patients. This improved quality of life is particularly important in paediatric patients, who may live for many years with the long-term effects of radiotherapy. Notably, signs and symptoms occurring after radiotherapy may not be due to the treatment but to an exacerbation of existing conditions or to the development of new diseases. Although differential diagnosis may be difficult, it has important consequences for patients.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1038/s41572-019-0064-5en
dc.titleRadiotherapy toxicityen
dc.typeArticleen
dc.contributor.departmentDepartment of Medical Oncology, The Christie NHS Foundation Trust, Manchester M204BX, United Kingdomen
dc.identifier.journalNature Reviews Disease Primersen
dc.description.noteen]


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