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    Optimal management of brain metastases in oncogenic-driven non-small cell lung cancer (NSCLC)

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    Authors
    Andratschke, N
    Kraft, J
    Nieder, C
    Tay, Rebecca
    Califano, Raffaele
    Soffietti, R
    Guckenberger, M
    Affiliation
    Department of Gynecology and Gynecological Oncology, Agaplesion Markus Hospital, Frankfurt am Main, Germany
    Issue Date
    2019
    
    Metadata
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    Abstract
    Brain metastases are common events in the natural course of many advanced solid cancers like breast, lung and renal cancer or melanoma with a cumulative risk of 10-30% in adults [1-3]. Non-small cell lung cancer (NSCLC) is associated with an increased risk for the development of brain metastases and the prognosis until recently has been poor except for some patients' subgroups and depending on the disease-specific GPA prognostic factors [4]. For patients receiving only best supportive care, average survival is about 3 months and it is assumed that through additional whole brain radiotherapy average survival may be improved up to 6-9 months in selected patients [5]. In recent years, complex treatment strategies for different solid tumors have been developed and this has impacted on the general management of brain metastases. Most of the studies on brain metastases have included different histological subtypes and therefore have made tumor- specific recommendations difficult. In this review, we discuss the current evidence on management of brain metastases and incorporate specific recent data on oncogenic-driven NSCLC in order to suggest recommendations on the optimal management of brain metastases in this subgroup of NSCLC where formal level I evidence is lacking.
    Citation
    Andratschke N, Kraft J, Nieder C, Tay R, Califano R, Soffietti R, et al. Optimal management of brain metastases in oncogenic-driven non-small cell lung cancer (NSCLC). Lung Cancer. 2019;129:63-71.
    Journal
    Lung Cancer
    URI
    http://hdl.handle.net/10541/621698
    DOI
    10.1016/j.lungcan.2018.12.009
    PubMed ID
    30797493
    Additional Links
    https://dx.doi.org/10.1016/j.lungcan.2018.12.009
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.lungcan.2018.12.009
    Scopus Count
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