Predictors of weight gain in a cohort of premenopausal early breast cancer patients receiving chemotherapy
Howell, Sacha J
AffiliationMedical Oncology Department, Centre Leon Berard, Lyon, France
MetadataShow full item record
AbstractAIM: In breast cancer patients, post chemotherapy weight gain is linked with increased risk of cancer recurrence. We prospectively studied a cohort of premenopausal women receiving contemporary chemotherapy following a diagnosis of breast cancer to examine factors predicting weight increase. METHODS: Between May 2005 and January 2008, 523 patients from the Prospective Outcomes in Sporadic versus Hereditary (POSH) breast cancer study entered this sub-study comparing weight prior to chemotherapy and weight and waist/hip measurements 12-months following chemotherapy. RESULTS: Data from 380 patients were available. Mean (standard deviation [SD]) pre-treatment body mass index (BMI) was 26.3 (5.6) kg/m2; 30% women gained?>?5% body weight during the study period. Lower BMI at diagnosis predicted greater subsequent post treatment weight gain (4.3% relative weight gain for those in the 1st quartile of BMI compared to 0.8% for those in the 4th quartile; r?=?-0.22; p?<?0.001). No link to chemotherapy regimens, cigarette smoking, previous parity or chemotherapy induced amenorrhoea was noted. A total of 44% of women had central obesity (post-treatment waist measurement of ?88?cm). CONCLUSIONS: Almost a third of premenopausal patients receiving adjuvant chemotherapy for breast cancer will gain clinically significant weight and over 40% will have central obesity 12-months following diagnosis. A greater weight gain is predicted by lower pretreatment BMI.
CitationGandhi A, Copson E, Eccles D, Durcan L, Howell A, Morris J, et al. Predictors of weight gain in a cohort of premenopausal early breast cancer patients receiving chemotherapy. Breast. 2019;45:1-6.
- Profiles of lipids, blood pressure and weight changes among premenopausal Chinese breast cancer patients after adjuvant chemotherapy.
- Authors: Yeo W, Mo FKF, Pang E, Suen JJS, Koh J, Loong HHF, Yip CCH, Ng RYW, Yip CHW, Tang NLS, Liem GS
- Issue date: 2017 Jul 27
- Changes in weight, body composition, and physical activity among patients with breast cancer under adjuvant chemotherapy.
- Authors: Jung GH, Kim JH, Chung MS
- Issue date: 2020 Feb
- Changes in weight, body composition, and factors influencing energy balance among premenopausal breast cancer patients receiving adjuvant chemotherapy.
- Authors: Demark-Wahnefried W, Peterson BL, Winer EP, Marks L, Aziz N, Marcom PK, Blackwell K, Rimer BK
- Issue date: 2001 May 1
- Determinants of Weight Gain During Adjuvant Endocrine Therapy and Association of Such Weight Gain With Recurrence in Long-term Breast Cancer Survivors.
- Authors: Raghavendra A, Sinha AK, Valle-Goffin J, Shen Y, Tripathy D, Barcenas CH
- Issue date: 2018 Feb
- Body weight changes after adjuvant chemotherapy of patients with breast cancer: results of a Mexican cohort study.
- Authors: Vargas-Meza A, Chavez-Tostado M, Cortes-Flores AO, Urias-Valdez D, Delgado-Gomez M, Morgan-Villela G, Zuloaga-Fernandez Del Valle C, Jimenez-Tornero J, Zuloaga-Fernandez Del Valle R, Fuentes-Orozco C, García-Rentería J, Rendón-Félix J, Cuesta-Márquez L, Gonzalez-Ojeda A
- Issue date: 2017 Sep