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    Clinical presentation, diagnosis, and staging of cholangiocarcinoma

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    Authors
    Forner, A
    Vidili, G
    Rengo, M
    Bujanda, L
    Ponz-Sarvise, M
    Lamarca, Angela
    Affiliation
    Department of Radiotherapy, University Medical Center Utrecht, the Netherlands
    Issue Date
    2019
    
    Metadata
    Show full item record
    Abstract
    Cholangiocarcinoma (CCA) is a heterogeneous group of tumours, derived from cells of the biliary tree, which represent the second most frequent primary liver tumour. According to the most recent classifications, CCA can be subdivided into intrahepatic (iCCA) and extrahepatic (eCCA) which include perihilar (pCCA) and distal (dCCA) CCA. CCA are usually identified at advanced stages, when the primary tumour grows enough to produce a large liver mass or when jaundice has developed because of biliary tree obstruction. The ongoing challenges in the identification of risk factors and definition of a specific population at higher risk of developing CCA are the main challenges for the development of screening programs. Therefore, late diagnosis remains an unresolved issue in CCA. Imaging plays an important role in the detection and characterization of CCA, helping with radiological diagnosis, guiding biopsy procedures and allowing staging of the tumour. This review focuses on clinical presentations and diagnosis and staging techniques of CCA.
    Citation
    Forner A, Vidili G, Rengo M, Bujanda L, Ponz-Sarvise M, Lamarca A. Clinical presentation, diagnosis, and staging of cholangiocarcinoma. Liver Int. 2019.
    Journal
    Liver International
    URI
    http://hdl.handle.net/10541/621690
    DOI
    10.1111/liv.14086
    PubMed ID
    30831002
    Additional Links
    https://dx.doi.org/10.1111/liv.14086
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1111/liv.14086
    Scopus Count
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