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dc.contributor.authorJiang, X
dc.contributor.authorFinucane, H
dc.contributor.authorSchumacher, F
dc.contributor.authorSchmit, S
dc.contributor.authorTyrer, J
dc.contributor.authorHan, Y
dc.contributor.authorMichailidou, K
dc.contributor.authorLesseur, C
dc.contributor.authorKuchenbaecker, K
dc.contributor.authorDennis, J
dc.contributor.authorConti, D
dc.contributor.authorCasey, G
dc.contributor.authorGaudet, M
dc.contributor.authorHuyghe, J
dc.contributor.authorAlbanes, D
dc.contributor.authorAldrich, M
dc.contributor.authorAndrew, A
dc.contributor.authorAndrulis, I
dc.contributor.authorAnton-Culver, H
dc.contributor.authorAntoniou, A
dc.contributor.authorAntonenkova, N
dc.contributor.authorArnold, S
dc.contributor.authorAronson, K
dc.contributor.authorArun, B
dc.contributor.authorBandera, E
dc.contributor.authorBarkardottir, R
dc.contributor.authorBarnes, D
dc.contributor.authorBatra, J
dc.contributor.authorBeckmann, M
dc.contributor.authorBenitez, J
dc.contributor.authorBenlloch, S
dc.contributor.authorBerchuck, A
dc.contributor.authorBerndt, S
dc.contributor.authorBickeboller, H
dc.contributor.authorBien, S
dc.contributor.authorBlomqvist, C
dc.contributor.authorBoccia, S
dc.contributor.authorBogdanova, N
dc.contributor.authorBojesen, S
dc.contributor.authorBolla, M
dc.contributor.authorBrauch, H
dc.contributor.authorBrenner, H
dc.contributor.authorBrenton, J
dc.contributor.authorBrook, M
dc.contributor.authorBrunet, J
dc.contributor.authorBrunnstrom, H
dc.contributor.authorBuchanan, D
dc.contributor.authorBurwinkel, B
dc.contributor.authorButzow, R
dc.contributor.authorCadoni, G
dc.contributor.authorCaldes, T
dc.contributor.authorCaligo, M
dc.contributor.authorCampbell, I
dc.contributor.authorCampbell, P
dc.contributor.authorCancel-Tassin, G
dc.contributor.authorCannon-Albright, L
dc.contributor.authorCampa, D
dc.contributor.authorCaporaso, N
dc.contributor.authorCarvalho, A
dc.contributor.authorChan, A
dc.contributor.authorChang-Claude, J
dc.contributor.authorChanock, S
dc.contributor.authorChen, C
dc.contributor.authorChristiani, D
dc.contributor.authorClaes, K
dc.contributor.authorClaessens, F
dc.contributor.authorClements, J
dc.contributor.authorCollee, M
dc.contributor.authorCorrea, C
dc.contributor.authorCouch, J
dc.contributor.authorCox, A
dc.contributor.authorCunningham, M
dc.contributor.authorCybulski, C
dc.contributor.authorCzene, K
dc.contributor.authorDaly, B
dc.contributor.authordefazio, A
dc.contributor.authorDevilee, P
dc.contributor.authorDiez, O
dc.contributor.authorGago-Dominguez, M
dc.contributor.authorDonovan, J
dc.contributor.authorDork, T
dc.contributor.authorDuell, E
dc.contributor.authorDunning, A
dc.contributor.authorDwek, M
dc.contributor.authorEccles, D
dc.contributor.authorEdlund, C
dc.contributor.authorEdwards, D
dc.contributor.authorEllberg, C
dc.contributor.authorEvans, D
dc.contributor.authorFasching, P
dc.contributor.authorFerris, R
dc.contributor.authorLiloglou, T
dc.contributor.authorFigueiredo, J
dc.contributor.authorFletcher, O
dc.contributor.authorFortner, R
dc.contributor.authorFostira, F
dc.contributor.authorFranceschi, S
dc.contributor.authorFriedman, E
dc.contributor.authorGallinger, S
dc.contributor.authorGanz, P
dc.contributor.authorGarber, J
dc.contributor.authorGarcia-Saenz, J
dc.contributor.authorGayther, S
dc.contributor.authorGiles, G
dc.contributor.authorGodwin, A
dc.contributor.authorGoldberg, M
dc.contributor.authorGoldgar, D
dc.contributor.authorGoode, E
dc.contributor.authorGoodman, M
dc.contributor.authorGoodman, G
dc.contributor.authorGrankvist, K
dc.contributor.authorGreene, M
dc.contributor.authorGronberg, H
dc.contributor.authorGronwald, J
dc.contributor.authorGuenel, P
dc.contributor.authorHakansson, N
dc.contributor.authorHall, P
dc.contributor.authorHamann, U
dc.contributor.authorHamdy, F
dc.contributor.authorHamilton, R
dc.contributor.authorHampe, J
dc.contributor.authorHaugen, A
dc.contributor.authorHeitz, F
dc.contributor.authorHerrero, R
dc.contributor.authorHillemanns, P
dc.contributor.authorHoffmeister, M
dc.contributor.authorHogdall, E
dc.contributor.authorHong, Y
dc.contributor.authorHopper, J
dc.contributor.authorHoulston, R
dc.contributor.authorHulick, P
dc.contributor.authorHunter, D
dc.contributor.authorHuntsman, D
dc.contributor.authorIdos, G
dc.contributor.authorImyanitov, E
dc.contributor.authorIngles, S
dc.contributor.authorIsaacs, C
dc.contributor.authorJakubowska, A
dc.contributor.authorJames, P
dc.contributor.authorJenkins, M
dc.contributor.authorJohansson, M
dc.contributor.authorJohansson, M
dc.contributor.authorJohn, E
dc.contributor.authorJoshi, A
dc.contributor.authorKaneva, R
dc.contributor.authorKarlan, B
dc.contributor.authorKelemen, L
dc.contributor.authorKuhl, T
dc.contributor.authorKhaw, K
dc.contributor.authorKhusnutdinova, E
dc.contributor.authorKibel, A
dc.contributor.authorKiemeney, L
dc.contributor.authorKim, J
dc.contributor.authorKjaer, S
dc.contributor.authorKnight, J
dc.contributor.authorKogevinas, M
dc.contributor.authorKote-Jarai, Z
dc.contributor.authorKoutros, S
dc.contributor.authorKristensen, V
dc.contributor.authorKupryjanczyk, J
dc.contributor.authorLacko, M
dc.contributor.authorLam, S
dc.contributor.authorLambrechts, D
dc.contributor.authorLandi, M
dc.contributor.authorLazarus, P
dc.contributor.authorLe, N
dc.contributor.authorLee, E
dc.contributor.authorLejbkowicz, F
dc.contributor.authorLenz, H
dc.contributor.authorLeslie, G
dc.contributor.authorLessel, D
dc.contributor.authorLester, J
dc.contributor.authorLevine, D
dc.contributor.authorLi, L
dc.contributor.authorLi, C
dc.contributor.authorLindblom, A
dc.contributor.authorLindor, N
dc.contributor.authorLiu, G
dc.contributor.authorLoupakis, F
dc.contributor.authorLubinski, J
dc.contributor.authorMaehle, L
dc.contributor.authorMaier, C
dc.contributor.authorMannermaa, A
dc.contributor.authorLe Marchand, L
dc.contributor.authorMargolin, S
dc.contributor.authorMay, T
dc.contributor.authorMcGuffog, L
dc.contributor.authorMeindl, A
dc.contributor.authorMiddha, P
dc.contributor.authorMiller, A
dc.contributor.authorMilne, R
dc.contributor.authorMacInnis, R
dc.contributor.authorModugno, F
dc.contributor.authorMontagna, M
dc.contributor.authorMoreno, V
dc.contributor.authorMoysich, K
dc.contributor.authorMucci, L
dc.contributor.authorMuir, K
dc.contributor.authorMulligan, A
dc.contributor.authorNathanson, K
dc.contributor.authorNeal, D
dc.contributor.authorNess, A
dc.contributor.authorNeuhausen, S
dc.contributor.authorNevanlinna, H
dc.contributor.authorNewcomb, P
dc.contributor.authorNewcomb, L
dc.contributor.authorNielsen, F
dc.contributor.authorNikitina-Zake, L
dc.contributor.authorNordestgaard, B
dc.contributor.authorNussbaum, R
dc.contributor.authorOffit, K
dc.contributor.authorOlah, E
dc.contributor.authorAl, Olama, A
dc.contributor.authorOlopade, O
dc.contributor.authorOlshan, A
dc.contributor.authorOlsson, H
dc.contributor.authorOsorio, A
dc.contributor.authorPandha, H
dc.contributor.authorPark, J
dc.contributor.authorPashayan, N
dc.contributor.authorParsons, M
dc.contributor.authorPejovic, T
dc.contributor.authorPenney, K
dc.contributor.authorPeters, W
dc.contributor.authorPhelan, C
dc.contributor.authorPhipps, A
dc.contributor.authorPlaseska-Karanfilska, D
dc.contributor.authorPring, M
dc.contributor.authorProkofyeva, D
dc.contributor.authorRadice, P
dc.contributor.authorStefansson, K
dc.contributor.authorRamus, S
dc.contributor.authorRaskin, L
dc.contributor.authorRennert, G
dc.contributor.authorRennert, H
dc.contributor.authorvan, Rensburg, E
dc.contributor.authorRiggan, M
dc.contributor.authorRisch, A
dc.contributor.authorRisch, A
dc.contributor.authorRoobol, J
dc.contributor.authorRosenstein, S
dc.contributor.authorRossing, A
dc.contributor.authorDe, Ruyck, K
dc.contributor.authorSaloustros, E
dc.contributor.authorSandler, P
dc.contributor.authorSawyer, J
dc.contributor.authorSchabath, B
dc.contributor.authorSchleutker, J
dc.contributor.authorSchmidt, K
dc.contributor.authorSetiawan, W
dc.contributor.authorShen, H
dc.contributor.authorSiegel, E
dc.contributor.authorSieh, W
dc.contributor.authorSinger, C
dc.contributor.authorSlattery, M
dc.contributor.authorTownsend, Paul A
dc.contributor.authorWest, Catharine M L
dc.date.accessioned2019-03-29T14:22:27Z
dc.date.available2019-03-29T14:22:27Z
dc.date.issued2019en
dc.identifier.citationJiang X, Finucane K, Schumacher R, Schmit L, Tyrer P, Han Y, et al. Shared heritability and functional enrichment across six solid cancers. Nat Commun. 2019 Jan 25;10(1):431.en
dc.identifier.pmid30683880en
dc.identifier.doi10.1038/s41467-018-08054-4en
dc.identifier.urihttp://hdl.handle.net/10541/621650
dc.description.abstractQuantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (rg?=?0.57, p?=?4.6?×?10-8), breast and ovarian cancer (rg?=?0.24, p?=?7?×?10-5), breast and lung cancer (rg?=?0.18, p =1.5?×?10-6) and breast and colorectal cancer (rg?=?0.15, p?=?1.1?×?10-4). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1038/s41467-018-08054-4en
dc.titleShared heritability and functional enrichment across six solid cancersen
dc.typeArticleen
dc.contributor.departmentExperimental Cancer Medicine Team, The Christie NHS Foundation Trust, Manchesteren
dc.identifier.journalNature Communicationsen
dc.description.noteen]


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