Shared heritability and functional enrichment across six solid cancers
Authors
Jiang, XFinucane, H
Schumacher, F
Schmit, S
Tyrer, J
Han, Y
Michailidou, K
Lesseur, C
Kuchenbaecker, K
Dennis, J
Conti, D
Casey, G
Gaudet, M
Huyghe, J
Albanes, D
Aldrich, M
Andrew, A
Andrulis, I
Anton-Culver, H
Antoniou, A
Antonenkova, N
Arnold, S
Aronson, K
Arun, B
Bandera, E
Barkardottir, R
Barnes, D
Batra, J
Beckmann, M
Benitez, J
Benlloch, S
Berchuck, A
Berndt, S
Bickeboller, H
Bien, S
Blomqvist, C
Boccia, S
Bogdanova, N
Bojesen, S
Bolla, M
Brauch, H
Brenner, H
Brenton, J
Brook, M
Brunet, J
Brunnstrom, H
Buchanan, D
Burwinkel, B
Butzow, R
Cadoni, G
Caldes, T
Caligo, M
Campbell, I
Campbell, P
Cancel-Tassin, G
Cannon-Albright, L
Campa, D
Caporaso, N
Carvalho, A
Chan, A
Chang-Claude, J
Chanock, S
Chen, C
Christiani, D
Claes, K
Claessens, F
Clements, J
Collee, M
Correa, C
Couch, J
Cox, A
Cunningham, M
Cybulski, C
Czene, K
Daly, B
DeFazio, A.
Devilee, P
Diez, O
Gago-Dominguez, M
Donovan, J
Dork, T
Duell, E
Dunning, A
Dwek, M
Eccles, D
Edlund, C
Edwards, D
Ellberg, C
Evans, D
Fasching, P
Ferris, R
Liloglou, T
Figueiredo, J
Fletcher, O
Fortner, R
Fostira, F
Franceschi, S
Friedman, E
Gallinger, S
Ganz, P
Garber, J
Garcia-Saenz, J
Gayther, S
Giles, G
Godwin, A
Goldberg, M
Goldgar, D
Goode, E
Goodman, M
Goodman, G
Grankvist, K
Greene, M
Gronberg, H
Gronwald, J
Guenel, P
Hakansson, N
Hall, P
Hamann, U
Hamdy, F
Hamilton, R
Hampe, J
Haugen, A
Heitz, F
Herrero, R
Hillemanns, P
Hoffmeister, M
Hogdall, E
Hong, Y
Hopper, J
Houlston, R
Hulick, P
Hunter, D
Huntsman, D
Idos, G
Imyanitov, E
Ingles, S
Isaacs, C
Jakubowska, A
James, P
Jenkins, M
Johansson, M
Johansson, M
John, E
Joshi, A
Kaneva, R
Karlan, B
Kelemen, L
Kuhl, T
Khaw, K
Khusnutdinova, E
Kibel, A
Kiemeney, L
Kim, J
Kjaer, S
Knight, J
Kogevinas, M
Kote-Jarai, Z
Koutros, S
Kristensen, V
Kupryjanczyk, J
Lacko, M
Lam, S
Lambrechts, D
Landi, M
Lazarus, P
Le, N
Lee, E
Lejbkowicz, F
Lenz, H
Leslie, G
Lessel, D
Lester, J
Levine, D
Li, L
Li, C
Lindblom, A
Lindor, N
Liu, G
Loupakis, F
Lubinski, J
Maehle, L
Maier, C
Mannermaa, A
Le Marchand, L
Margolin, S
May, T
McGuffog, L
Meindl, A
Middha, P
Miller, A
Milne, R
MacInnis, R
Modugno, F
Montagna, M
Moreno, V
Moysich, K
Mucci, L
Muir, K
Mulligan, A
Nathanson, K
Neal, D
Ness, A
Neuhausen, S
Nevanlinna, H
Newcomb, P
Newcomb, L
Nielsen, F
Nikitina-Zake, L
Nordestgaard, B
Nussbaum, R
Offit, K
Olah, E
Al Olama, A
Olopade, O
Olshan, A
Olsson, H
Osorio, A
Pandha, H
Park, J
Pashayan, N
Parsons, M
Pejovic, T
Penney, K
Peters, W
Phelan, C
Phipps, A
Plaseska-Karanfilska, D
Pring, M
Prokofyeva, D
Radice, P
Stefansson, K
Ramus, S
Raskin, L
Rennert, G
Rennert, H
van, Rensburg, E
Riggan, M
Risch, A
Risch, A
Roobol, J
Rosenstein, S
Rossing, A
De, Ruyck, K
Saloustros, E
Sandler, P
Sawyer, J
Schabath, B
Schleutker, J
Schmidt, K
Setiawan, W
Shen, H
Siegel, E
Sieh, W
Singer, C
Slattery, M
Townsend, Paul A
West, Catharine M L
Affiliation
Experimental Cancer Medicine Team, The Christie NHS Foundation Trust, ManchesterIssue Date
2019
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Show full item recordAbstract
Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (rg?=?0.57, p?=?4.6?×?10-8), breast and ovarian cancer (rg?=?0.24, p?=?7?×?10-5), breast and lung cancer (rg?=?0.18, p =1.5?×?10-6) and breast and colorectal cancer (rg?=?0.15, p?=?1.1?×?10-4). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis.Citation
Jiang X, Finucane K, Schumacher R, Schmit L, Tyrer P, Han Y, et al. Shared heritability and functional enrichment across six solid cancers. Nat Commun. 2019 Jan 25;10(1):431.Journal
Nature CommunicationsDOI
10.1038/s41467-018-08054-4PubMed ID
30683880Additional Links
https://dx.doi.org/10.1038/s41467-018-08054-4Type
ArticleLanguage
enae974a485f413a2113503eed53cd6c53
10.1038/s41467-018-08054-4
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