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    The diverse consequences of FOXC1 deregulation in cancer

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    Authors
    Gilding, LN
    Somervaille, Tim CP
    Affiliation
    Leukaemia Biology Laboratory, Cancer Research UK Manchester Institute, The University of Manchester, Manchester M20 4JG, UK.
    Issue Date
    2019
    
    Metadata
    Show full item record
    Abstract
    Forkhead box C1 (FOXC1) is a transcription factor with essential roles in mesenchymal lineage specification and organ development during normal embryogenesis. In keeping with these developmental properties, mutations that impair the activity of FOXC1 result in the heritable Axenfeld-Rieger Syndrome and other congenital disorders. Crucially, gain of FOXC1 function is emerging as a recurrent feature of malignancy; FOXC1 overexpression is now documented in more than 16 cancer types, often in association with an unfavorable prognosis. This review explores current evidence for FOXC1 deregulation in cancer and the putative mechanisms by which FOXC1 confers its oncogenic effects.
    Citation
    Gilding LN, Somervaille TCP. The diverse consequences of FOXC1 deregulation incCancer. Cancers (Basel). 2019 Feb 5;11(2).
    Journal
    Cancers
    URI
    http://hdl.handle.net/10541/621641
    DOI
    10.3390/cancers11020184
    PubMed ID
    30764547
    Additional Links
    https://dx.doi.org/10.3390/cancers11020184
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.3390/cancers11020184
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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