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    Stage at diagnosis for children with blood cancers in Australia: application of the Toronto Paediatric Cancer Stage Guidelines in a population-based national childhood cancer registry

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    Authors
    Youlden, DR
    Gupta, S
    Frazier, AL
    Moore, AS
    Baade, PD
    Valery, PC
    Green, Adèle C
    Aitken, JF
    Affiliation
    Cancer Council Queensland, Brisbane, Queensland, Australia
    Issue Date
    2019
    
    Metadata
    Show full item record
    Abstract
    BACKGROUND: Information on stage at diagnosis for childhood blood cancers is essential for surveillance but is not available on a population basis in most countries. Our aim was to apply the internationally endorsed Toronto Paediatric Cancer Stage Guidelines to children (<15 years) with acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), Hodgkin lymphoma (HL), or non-Hodgkin lymphoma (NHL) and to assess differences in survival by stage at diagnosis. PROCEDURE: Stage was defined by extent of involvement of the central nervous system (CNS) for ALL and AML and using the Ann Arbor and St Jude-Murphy systems for HL and NHL, respectively. The study cohort was drawn from the population-based Australian Childhood Cancer Registry, consisting of children diagnosed with one of these four blood cancers between 2006 and 2014 with follow-up to 2015. Five-year observed survival was estimated from the Kaplan-Meier method. RESULTS: Stage was assigned to 2201 of 2351 eligible patients (94%), ranging from 85% for AML to 95% for ALL, HL, and NHL. Survival following ALL varied from 94% (95% CI = 93%-95%) for CNS1 disease to 89% (95% CI = 79%-94%) for CNS2 (P = 0.07), whereas for AML there was essentially no difference in survival between CNS- (77%) and CNS+ disease (78%; P = 0.94). Nearly all children with HL survived for five years. There was a trend (P = 0.04) toward worsening survival with higher stage for NHL. CONCLUSIONS: These results provide the first population-wide picture of the distribution and outcomes for childhood blood cancers in Australia by extent of disease at diagnosis and provide a baseline for future comparisons.
    Citation
    Youlden DR, Gupta S, Frazier AL, Moore AS, Baade PD, Valery PC, et al. Stage at diagnosis for children with blood cancers in Australia: application of the Toronto Paediatric Cancer Stage Guidelines in a population-based national childhood cancer registry. Pediatr Blood Cancer. 2019 Feb 25:e27683.
    Journal
    Pediatric Blood & Cancer
    URI
    http://hdl.handle.net/10541/621639
    DOI
    10.1002/pbc.27683
    PubMed ID
    30803139
    Additional Links
    https://dx.doi.org/10.1002/pbc.27683
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1002/pbc.27683
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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