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    Stage at diagnosis for childhood solid cancers in Australia: a population-based study

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    Authors
    Youlden, DR
    Frazier, AL
    Gupta, S
    Pritchard-Jones, K
    Kirby, ML
    Baade, PD
    Green, Adèle C
    Valery, PC
    Aitken, JF
    Affiliation
    Cancer Council Queensland, Brisbane, Australia; Menzies Health Institute Queensland, Griffith University, Gold Coast, Australia
    Issue Date
    2019
    
    Metadata
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    Abstract
    BACKGROUND: Stage of cancer at diagnosis is one of the strongest predictors of survival and is essential for population cancer surveillance, comparison of cancer outcomes and to guide national cancer control strategies. Our aim was to describe, for the first time, the distribution of cases by stage at diagnosis and differences in stage-specific survival on a population basis for a range of childhood solid cancers in Australia. METHODS: The study cohort was drawn from the population-based Australian Childhood Cancer Registry and comprised children (<15 years) diagnosed with one of 12 solid malignancies between 2006 and 2014. Stage at diagnosis was assigned according to the Toronto Paediatric Cancer Stage Guidelines. Observed (all cause) survival was calculated using the Kaplan-Meier method, with follow-up on mortality available to 31 December 2015. RESULTS: Almost three-quarters (1256 of 1760 cases, 71%) of children in the study had localised or regional disease at diagnosis, varying from 43% for neuroblastoma to 99% for retinoblastoma. Differences in 5-year observed survival by stage were greatest for osteosarcoma (localised 85% (95% CI?=?72%-93%) versus metastatic 37% (15%-59%)), neuroblastoma (localised 98% (91%-99%) versus metastatic 60% (52%-67%)), rhabdomyosarcoma (localised 85% (71%-93%) versus metastatic 53% (34%-69%)), and medulloblastoma (localised 69% (61%-75%) versus metastases to spine 42% (27%-57%)). CONCLUSION: The stage-specific information presented here provides a basis for comparison with other international population cancer registries. Understanding variations in survival by stage at diagnosis will help with the targeted formation of initiatives to improve outcomes for children with cancer.
    Citation
    Youlden DR, Frazier AL, Gupta S, Pritchard-Jones K, Kirby ML, Baade PD, et al. Stage at diagnosis for childhood solid cancers in Australia: a population-based study. Cancer Epidemiol. 2019 Mar 1;59:208-14.
    Journal
    Cancer Epidemiology
    URI
    http://hdl.handle.net/10541/621636
    DOI
    10.1016/j.canep.2019.02.013
    PubMed ID
    30831553
    Additional Links
    https://dx.doi.org/10.1016/j.canep.2019.02.013
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.canep.2019.02.013
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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