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    Biomarker concordance between primary colorectal cancer and its metastases

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    Authors
    Bhullar, DS
    Barriuso, Jorge
    Mullamitha, Saifee A
    Saunders, Mark P
    O'Dwyer, Sarah T
    Aziz, Omer
    Affiliation
    Colorectal & Peritoneal Oncology Centre, The Christie NHS Foundation Trust, Manchester, UK;
    Issue Date
    2019
    
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    Abstract
    BACKGROUND: The use of biomarkers to target anti-EGFR treatments for metastatic colorectal cancer (CRC) is well-established, requiring molecular analysis of primary or metastatic biopsies. We aim to review concordance between primary CRC and its metastatic sites. METHODS: A systematic review and meta-analysis of all published studies (1991-2018) reporting on biomarker concordance between primary CRC and its metastatic site(s) was undertaken according to PRISMA guidelines using several medical databases. Studies without matched samples or using peripheral blood for biomarker analysis were excluded. FINDINGS: 61 studies including 3565 patient samples were included. Median biomarker concordance for KRAS (n =?50) was 93.7% [67-100], NRAS (n?=?11) was 100% [90-100], BRAF (n?=?22) was 99.4% [80-100], and PIK3CA (n?=?17) was 93% [42-100]. Meta-analytic pooled discordance was 8% for KRAS (95% CI?=?5-10%), 8% for BRAF (95% CI?=?5-10%), 7% for PIK3CA (95% CI?=?2-13%), and 28% overall (95% CI?=?14-44%). The liver was the most commonly biopsied metastatic site (n?=?2276), followed by lung (n?=?438), lymph nodes (n?=?1123), and peritoneum (n?=?132). Median absolute concordance in multiple biomarkers was 81% (5-95%). INTERPRETATION: Metastatic CRC demonstrates high concordance across multiple biomarkers, suggesting that molecular testing of either the primary or liver and lung metastasis is adequate. More research on colorectal peritoneal metastases is required.
    Citation
    Bhullar DS, Barriuso J, Mullamitha S, Saunders MP, O'Dwyer ST, Aziz O. Biomarker concordance between primary colorectal cancer and its metastases. EBioMedicine. 2019 Feb;40:363-74.
    Journal
    EBioMedicine
    URI
    http://hdl.handle.net/10541/621626
    DOI
    10.1016/j.ebiom.2019.01.050
    PubMed ID
    30733075
    Additional Links
    https://dx.doi.org/10.1016/j.ebiom.2019.01.050
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.ebiom.2019.01.050
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