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    Unmet medical needs in pulmonary neuroendocrine (carcinoid) neoplasms.

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    Authors
    Baudin, E
    Hayes, A
    Scoazec, J
    Filosso, P
    Lim, E
    Kaltsas, G
    Frilling, A
    Chen, J
    Kos-Kudla, B
    Gorbunova, V
    Wiedenmann, B
    van, Dijkum E
    Cwikla, J
    Falkerby, J
    Valle, Juan W
    Kulke, M
    Caplin, M
    Show allShow less
    Affiliation
    Oncologie Endocrinienne et Médecine Nucléaire, Institut Gustave Roussy, Villejuif
    Issue Date
    2019
    
    Metadata
    Show full item record
    Abstract
    Pulmonary carcinoids (PCs) display the common features of all well-differentiated neuroendocrine neoplasms (NEN) and are classified as low- and intermediate-grade malignant tumours (i.e., typical and atypical carcinoid, respectively). There is a paucity of randomised studies dedicated to advanced PCs and management principles are drawn from the larger gastroenteropancreatic NEN experience. There is growing evidence that NEN anatomic subgroups have different biology and different responses to treatment and, therefore, should be investigated as separate entities in clinical trials. In this review, we discuss the existing evidence and limitations of tumour classification, diagnostics and staging, prognostication, and treatment in the setting of PC, with focus on unmet medical needs and directions for the future.
    Citation
    Baudin E, Hayes AR, Scoazec JY, Filosso PL, Lim E, Kaltsas G, et al. Unmet medical needs in pulmonary neuroendocrine (carcinoid) neoplasms. Neuroendocrinology. 2019;108(1):7-17.
    Journal
    Neuroendocrinology
    URI
    http://hdl.handle.net/10541/621585
    DOI
    10.1159/000493980
    PubMed ID
    30248673
    Additional Links
    https://dx.doi.org/10.1159/000493980
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1159/000493980
    Scopus Count
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