Unmet medical needs in pulmonary neuroendocrine (carcinoid) neoplasms.
Authors
Baudin, EHayes, A
Scoazec, J
Filosso, P
Lim, E
Kaltsas, G
Frilling, A
Chen, J
Kos-Kudla, B
Gorbunova, V
Wiedenmann, B
van, Dijkum E
Cwikla, J
Falkerby, J
Valle, Juan W
Kulke, M
Caplin, M
Affiliation
Oncologie Endocrinienne et Médecine Nucléaire, Institut Gustave Roussy, VillejuifIssue Date
2019
Metadata
Show full item recordAbstract
Pulmonary carcinoids (PCs) display the common features of all well-differentiated neuroendocrine neoplasms (NEN) and are classified as low- and intermediate-grade malignant tumours (i.e., typical and atypical carcinoid, respectively). There is a paucity of randomised studies dedicated to advanced PCs and management principles are drawn from the larger gastroenteropancreatic NEN experience. There is growing evidence that NEN anatomic subgroups have different biology and different responses to treatment and, therefore, should be investigated as separate entities in clinical trials. In this review, we discuss the existing evidence and limitations of tumour classification, diagnostics and staging, prognostication, and treatment in the setting of PC, with focus on unmet medical needs and directions for the future.Citation
Baudin E, Hayes AR, Scoazec JY, Filosso PL, Lim E, Kaltsas G, et al. Unmet medical needs in pulmonary neuroendocrine (carcinoid) neoplasms. Neuroendocrinology. 2019;108(1):7-17.Journal
NeuroendocrinologyDOI
10.1159/000493980PubMed ID
30248673Additional Links
https://dx.doi.org/10.1159/000493980Type
ArticleLanguage
enae974a485f413a2113503eed53cd6c53
10.1159/000493980