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    Mesenchymal stromal cells for acute graft-versus-host disease: response at 1 week predicts probability of survival.

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    Authors
    Galleu, A
    Milojkovic, D
    Deplano, S
    Szydlo, R
    Loaiza, S
    Wynn, R
    Marks, D
    Richardson, D
    Orchard, K
    Kanfer, E
    Tholouli, E
    Saif, M
    Sivaprakasam, P
    Lawson, S
    Bloor, Adrian
    Pagliuca, A
    Potter, V
    Mehra, V
    Snowden, J
    Vora, A
    Kishore, B
    Hunter, H
    Apperley, J
    Dazzi, F
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    Affiliation
    King's College London, London, UK
    Issue Date
    2019
    
    Metadata
    Show full item record
    Abstract
    Mesenchymal stromal cells (MSCs) have been successfully used for the treatment of steroid-resistant graft-versus-host-disease (GvHD). However, the lack of early predictors of clinical responses impacts on the time at which to add further treatment and consequently the design of informative clinical trials. Here, we present the UK experience of one of the largest cohorts of GvHD patients undergoing MSC infusions so far reported. We show that clinical responses assessed as early as 1 week after MSC infusion predict patients' overall survival. In our cohort, cell dose, patients' age and type of organ involvement are crucial factors associated with clinical responses.
    Citation
    Galleu A, Milojkovic D, Deplano S, Szydlo R, Loaiza S, Wynn R, et al. Mesenchymal stromal cells for acute graft-versus-host disease: response at 1 week predicts probability of survival. Br J Haematol. 2019 Jan 13.
    Journal
    British Journal of Haematology
    URI
    http://hdl.handle.net/10541/621578
    DOI
    10.1111/bjh.15749
    PubMed ID
    30637732
    Additional Links
    https://dx.doi.org/10.1111/bjh.15749
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1111/bjh.15749
    Scopus Count
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    All Christie Publications

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