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    BA08: An open-label, single-arm, non-randomised, phase 2 trial of cisplatin, methotrexate and vinblastine (CMV) for pure squamous cell cancer of the urinary tract.

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    Authors
    Griffiths, G
    Cowan, Richard A
    Grigor, K
    Uscinska, B
    Sydes, M
    Russell, M
    Affiliation
    Southampton Clinical Trials Unit, University of Southampton, Southampton, United Kingdom
    Issue Date
    2019
    
    Metadata
    Show full item record
    Abstract
    BACKGROUND: Pure squamous cell carcinoma (SCC) of the urinary tract is rare in the UK and has a poor prognosis compared with transitional cell carcinoma (TCC). Cisplatin based chemotherapy has been shown to be effective in TCC. METHODS: Patients with T3-T4, pelvic relapsed, nodal or metastatic SCC of the urinary tract were recruited into an open-label, single-arm, non-randomised, phase 2 trial evaluating the activity and safety of cisplatin, methotrexate and vinblastine (CMV) chemotherapy. CMV was given as three 21-day cycles of methotrexate 30mg/m2 (day 1 & 8), vinblastine 4mg/m2 (day 1 & 8) and cisplatin 100mg/m2 (day 2). RESULTS: 38 patients were recruited. Overall response was 39% (95% CI 24%, 55%)-13% CR and 26% PR. Median OS was 7.8 months (95% CI 3.4, 12.6) with 39% 1-year survival. Toxicity was acceptable. CONCLUSION: CMV is well tolerated and active in patients with pure SCC of the urinary tract.
    Citation
    Griffiths GO, Cowan RA, Grigor KM, Uscinska BM, Sydes M, Russell M. BA08: An open-label, single-arm, non-randomised, phase 2 trial of cisplatin, methotrexate and vinblastine (CMV) for pure squamous cell cancer of the urinary tract. PLoS One. 2019;14(1):e0210785.
    Journal
    PloS one
    URI
    http://hdl.handle.net/10541/621573
    DOI
    10.1371/journal.pone.0210785
    PubMed ID
    30650143
    Additional Links
    https://dx.doi.org/10.1371/journal.pone.0210785
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1371/journal.pone.0210785
    Scopus Count
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