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    Oestradiol measurement during fulvestrant treatment for breast cancer.

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    Authors
    Owen, L
    Monaghan, Phillip J
    Armstrong, Anne C
    Keevil, B
    Higham, Claire E
    Salih, Zena
    Howell, Sacha J
    Affiliation
    Biochemistry Department, Wythenshawe Hospital, Wythenshawe, M23 9LT, UK
    Issue Date
    2019
    
    Metadata
    Show full item record
    Abstract
    Biochemical evaluation of menopausal status is used to inform treatment decisions, including clinical trial eligibility in women with oestrogen receptor positive breast cancer. However, fulvestrant may interfere with oestradiol immunoassays and confound accurate assessment in this context. We conducted a service evaluation of two immunoassays and an LC-MS/MS assay to determine the extent of the interference. Serum oestradiol levels were analysed by two immunoassays (Siemens Centaur XP and Abbott Architect) and liquid chromatography-tandem mass spectrometry (LC/MS/MS). Immunoassay gave higher serum oestradiol results than LC-MS/MS at low concentrations, with improved analytical sensitivity demonstrated by LC-MS/MS. Cross-reactivity of fulvestrant was observed for each immunoassay. We have shown that two commonly used immunoassays do not demonstrate the required sensitivity or specificity for the measurement of oestradiol in a breast cancer population. For patients receiving fulvestrant, spurious results may be generated that could impact treatment decisions. LC-MS/MS is recommended in this setting.
    Citation
    Owen LJ, Monaghan PJ, Armstrong A, Keevil BG, Higham C, Salih Z, et al. Oestradiol measurement during fulvestrant treatment for breast cancer. Br J Cancer. 2019 Jan 25.
    Journal
    British Journal of Cancer
    URI
    http://hdl.handle.net/10541/621563
    DOI
    10.1038/s41416-019-0378-9
    PubMed ID
    30679781
    Additional Links
    https://dx.doi.org/10.1038/s41416-019-0378-9
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1038/s41416-019-0378-9
    Scopus Count
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