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dc.contributor.authorValle, Juan W
dc.contributor.authorBorbath, I
dc.contributor.authorRosbrook, B
dc.contributor.authorFernandez, K
dc.contributor.authorRaymond, E
dc.date.accessioned2019-03-04T12:32:42Z
dc.date.available2019-03-04T12:32:42Z
dc.date.issued2019en
dc.identifier.citationValle JW, Borbath I, Rosbrook B, Fernandez K, Raymond E. Sunitinib in patients with pancreatic neuroendocrine tumors: update of safety data. Future Oncol. 2019 Jan 31.en
dc.identifier.pmid30701988en
dc.identifier.doi10.2217/fon-2018-0882en
dc.identifier.urihttp://hdl.handle.net/10541/621557
dc.description.abstractAIM: To describe the long-term safety of sunitinib in patients with progressive, well-differentiated, advanced/metastatic pancreatic neuroendocrine tumors. PATIENTS & METHODS: Sunitinib- and placebo-treated patients from the Phase III study continued to receive sunitinib (37.5 mg on a continuous daily-dosing regimen) in two open-label extension studies. RESULTS: Median (range) treatment exposure: 30.2 (0.7-269.4) and 87.1 (3.9-319.4) weeks for medium-term (n = 41) and long-term-treated (n = 61) populations, respectively. All patients experienced ?1 adverse event (AE); 47 (45.6%) reported serious AEs. Common all-causality AEs: diarrhea (63.1%); neutropenia (43.7%); abdominal pain (40.8%). Fifteen (14.6%) patients discontinued treatment due to treatment-related AEs. CONCLUSION: The safety of extended sunitinib treatment was consistent with the known safety profile of sunitinib in pancreatic neuroendocrine tumorsen
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.2217/fon-2018-0882en
dc.titleSunitinib in patients with pancreatic neuroendocrine tumors: update of safety data.en
dc.typeArticleen
dc.contributor.departmentDivision of Cancer Sciences/Department of Medical Oncology, The Christie NHS Foundation Trust, University of Manchester, Manchester M20 4BX, UKen
dc.identifier.journalFuture Oncologyen
dc.description.noteen]
refterms.dateFOA2019-03-07T17:32:30Z


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