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    Molecular characterisation and liquid biomarkers in carcinoma of unknown primary (CUP): taking the 'U' out of 'CUP'.

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    Authors
    Conway, Alicia-Marie
    Mitchell, Claire L
    Kilgour, Elaine
    Brady, Ged
    Dive, Caroline
    Cook, Natalie
    Affiliation
    The Christie NHS Foundation Trust, Wilmslow Road, Manchester
    Issue Date
    2019
    
    Metadata
    Show full item record
    Abstract
    Cancers of Unknown Primary (CUP) comprise a heterogeneous clinical entity of confirmed metastatic cancer where the primary site of origin is undetectable. It has a poor prognosis with limited treatment options. CUP is historically under-researched; however, understanding its biology has the potential to not only improve treatment and survival by implementation of biomarkers for patient management, but also to greatly contribute to our understanding of carcinogenesis and metastasis across all cancer types. Here we review the current advances in CUP research and explore the debated hypotheses underlying its biology. The evolution of molecular profiling and tissue-of-origin classifiers have the potential to transform the diagnosis, classification and therapeutic management of patients with CUP but robust evidence to support widespread use is lacking. Precision medicine has transformed treatment strategy in known tumour types; in CUP, however, there remains a clinical need for a better understanding of molecular characteristics to establish the potential role of novel or existing therapeutics. The emergence of liquid biopsies as a source of predictive and prognostic biomarkers within known tumour types is gaining rapid ground and this review explores the potential utility of liquid biopsies in CUP.
    Citation
    Conway AM, Mitchell C, Kilgour E, Brady G, Dive C, Cook N. Molecular characterisation and liquid biomarkers in carcinoma of unknown primary (CUP): taking the 'U' out of 'CUP'. Br J Cancer. 2019 Jan;120(2):141-53.
    Journal
    British Journal of Cancer
    URI
    http://hdl.handle.net/10541/621551
    DOI
    10.1038/s41416-018-0332-2
    PubMed ID
    30580378
    Additional Links
    https://dx.doi.org/10.1038/s41416-018-0332-2
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1038/s41416-018-0332-2
    Scopus Count
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