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dc.contributor.authorLarkin, J
dc.contributor.authorBrown, M
dc.contributor.authorArance, A
dc.contributor.authorHauschild, A
dc.contributor.authorQueirolo, P
dc.contributor.authorVecchio, M
dc.contributor.authorAscierto, P
dc.contributor.authorKrajsová, I
dc.contributor.authorSchachter, J
dc.contributor.authorNeyns, B
dc.contributor.authorGarbe, C
dc.contributor.authorSileni, VC
dc.contributor.authorMandalà, M
dc.contributor.authorGogas, H
dc.contributor.authorEspinosa, E
dc.contributor.authorHospers, G
dc.contributor.authorLorigan, Paul C
dc.contributor.authorNyakas, M
dc.contributor.authorGuminski, A
dc.contributor.authorLiszkay, G
dc.contributor.authorRutkowski, P
dc.contributor.authorMiller, W
dc.contributor.authorDonica, M
dc.contributor.authorMakrutzki, M
dc.contributor.authorBlank, C
dc.date.accessioned2019-02-08T15:20:10Z
dc.date.available2019-02-08T15:20:10Z
dc.date.issued2019en
dc.identifier.citationLarkin J, Brown MP, Arance AM, Hauschild A, Queirolo P, Vecchio MD, et al. An open-label, multicentre safety study of vemurafenib in patients with BRAF(V600)-mutant metastatic melanoma: final analysis and a validated prognostic scoring system. Eur J Cancer. 2019 Jan;107:175-85.en
dc.identifier.pmid30580112en
dc.identifier.doi10.1016/j.ejca.2018.11.018en
dc.identifier.urihttp://hdl.handle.net/10541/621536
dc.description.abstractBACKGROUND: The oncogenic BRAF inhibitor vemurafenib improves outcomes for patients with advanced BRAFV600 mutation-positive melanoma compared with cytotoxic chemotherapy. Vemurafenib is now approved for use in this patient population. PATIENTS AND METHODS: In this open-label, multicentre study, patients with previously treated or untreated melanoma and the BRAFV600 mutation received vemurafenib 960 mg twice daily. The primary endpoint was safety. In a post hoc analysis, overall survival (OS) was analysed according to a prognostic scoring system developed using Eastern Cooperative Oncology Group performance status, existence of brain metastases and baseline serum lactate dehydrogenase level. The index was validated using data from patients treated with vemurafenib or dacarbazine in three clinical trials and data from patients treated with vemurafenib plus cobimetinib in two studies. The study is registered with ClinicalTrials.gov (NCT01307397). RESULTS: Between March 2011 and January 2013, 3224 patients were enrolled, and 3219 patients received ?1 dose of vemurafenib (safety population); median follow-up time was 33.4 months. Vemurafenib's long-term benefits were confirmed, and no new safety signals identified. The prognostic index showed between-group differences in OS, with tight, non-overlapping confidence intervals. Validation in a pooled group of 666 vemurafenib-treated clinical trial patients revealed a similar pattern; the pattern was similar in 280 patients treated with vemurafenib plus cobimetinib. CONCLUSIONS: Final results from the vemurafenib safety study confirm vemurafenib's tolerability in BRAFV600 mutation-positive patients and resemble those seen in real-world clinical practice. This index may be useful in patients on combination therapy and as a basis for further.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1016/j.ejca.2018.11.018en
dc.titleAn open-label, multicentre safety study of vemurafenib in patients with BRAFV600-mutant metastatic melanoma: final analysis and a validated prognostic scoring systemen
dc.typeArticleen
dc.contributor.departmentRoyal Marsden NHS FT, Londonen
dc.identifier.journalEuropean Journal of Canceren
dc.description.noteen]


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