Experimental validation of estimated spatially variant radioisotope-specific point spread functions using published positron range simulations and fluorine-18 measurements.
AuthorsAnton-Rodriguez, Jose M
Julyan, Peter J
AffiliationDivision of Informatics, Imaging and Data Sciences, MAHSC, University of Manchester, Manchester, United Kingdom
MetadataShow full item record
AbstractIn this work we compare spatially variant radioisotope-specific point spread functions (PSFs) derived from published positron range data with measured data using a high resolution research tomograph (HRRT). Spatially variant PSFs were measured on a HRRT for fluorine-18, carbon-11 and gallium-68 using an array of printed point sources. For gallium-68, this required modification of the original design to handle its longer positron range. Using the fluorine-18 measurements and previously published data from Monte-Carlo simulations of positron range, estimated PSFs for carbon-11 and gallium-68 were calculated and compared with experimental data. A double 3D Gaussian function was fitted to the estimated and measured data and used to model the spatially varying PSFs over the scanner field of view (FOV). Differences between the measured and estimated PSFs were quantified using the full-width-at-half-maximum (FWHM) and full-width-at-tenth-maximum (FWTM) in the tangential, radial and axial directions. While estimated PSFs were generally in agreement with the measured PSFs over the entire FOV better agreement was observed (FWHM and FWTM differences of less than 10%) when using one of the two sets of positron range simulations, especially for gallium-68 and for the FWTM. Spatially variant radioisotope specific PSFs can be accurately estimated from fluorine-18 measurements and published positron range data. We have experimentally validated this approach for carbon-11 and gallium-68, and such an approach may be applicable to other radioisotopes such as oxygen-15 for which measurements are not practical.
CitationAnton-Rodriguez JM, Krokos G, Kotasidis F, Asselin MC, Morris O, Julyan P, et al. Experimental validation of estimated spatially variant radioisotope-specific point spread functions using published positron range simulations and fluorine-18 measurements. Phys Med Biol. 2018 Dec 7;63(24):24
JournalPhysics in Medicine and Biology
- Isotope specific resolution recovery image reconstruction in high resolution PET imaging.
- Authors: Kotasidis FA, Angelis GI, Anton-Rodriguez J, Matthews JC, Reader AJ, Zaidi H
- Issue date: 2014 May
- Full field spatially-variant image-based resolution modelling reconstruction for the HRRT.
- Authors: Angelis GI, Kotasidis FA, Matthews JC, Markiewicz PJ, Lionheart WR, Reader AJ
- Issue date: 2015 Mar
- The Impact of Positron Range on PET Resolution, Evaluated with Phantoms and PHITS Monte Carlo Simulations for Conventional and Non-conventional Radionuclides.
- Authors: Carter LM, Kesner AL, Pratt EC, Sanders VA, Massicano AVF, Cutler CS, Lapi SE, Lewis JS
- Issue date: 2020 Feb
- Single scan parameterization of space-variant point spread functions in image space via a printed array: the impact for two PET/CT scanners.
- Authors: Kotasidis FA, Matthews JC, Angelis GI, Noonan PJ, Jackson A, Price P, Lionheart WR, Reader AJ
- Issue date: 2011 May 21
- The design and physical characteristics of a small animal positron emission tomograph.
- Authors: Bloomfield PM, Rajeswaran S, Spinks TJ, Hume SP, Myers R, Ashworth S, Clifford KM, Jones WF, Byars LG, Young J
- Issue date: 1995 Jun