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dc.contributor.authorFarooq, Aen
dc.contributor.authorJorda, Men
dc.contributor.authorWhittington, Een
dc.contributor.authorKryvenko, Oen
dc.contributor.authorBraunhut, Ben
dc.contributor.authorPavan Nen
dc.contributor.authorProchazkova, Ken
dc.contributor.authorZhang, Len
dc.contributor.authorRai, Sen
dc.contributor.authorMiller, Teganen
dc.contributor.authorLiu, Jen
dc.contributor.authorSzabo, Aen
dc.contributor.authorIczkowski, Ken
dc.date.accessioned2019-02-08T15:20:08Z
dc.date.available2019-02-08T15:20:08Z
dc.date.issued2018en
dc.identifier.citationFarooq A, Jorda M, Whittington E, Kryvenko ON, Braunhut BL, Pavan N, et al. Rete testis invasion is consistent with pathologic stage T1 in germ cell tumors. Am J Clin Pathol. 2018 Dec 20.en
dc.identifier.pmid30576407en
dc.identifier.doi10.1093/ajcp/aqy168en
dc.identifier.urihttp://hdl.handle.net/10541/621526
dc.description.abstractOBJECTIVES: Rete testis invasion by germ cell tumors is frequently concomitant with lymphovascular or spermatic cord invasion (LVI/SCI); independent implications for staging are uncertain. METHODS: In total, 171 seminomas and 178 nonseminomatous germ cell tumors (NSGCTs; 46 had 1%-60% seminoma component) came from five institutions. Metastatic status at presentation, as a proxy for severity, was available for all; relapse data were unavailable for 152. Rete direct invasion (ReteD) and rete pagetoid spread (ReteP) were assessed. RESULTS: ReteP and ReteD were more frequent in seminoma than NSGCT. In seminoma, tumor size bifurcated at 3 cm or more or less than 3 cm predicted metastatic status. Tumors with ReteP or ReteD did not differ in size from those without invasions but were less than with LVI/SCI metastatic status or relapse did not show differences. In NSGCT, ReteP/ReteD did not correlate with size, metastatic status, or relapse. CONCLUSIONS: Findings support retaining American Joint Committee for Cancer pathologic T1 stage designation for rete testis invasion and pT1a/pT1b substaging of seminoma.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1093/ajcp/aqy168en
dc.titleRete testis invasion is consistent with pathologic stage T1 in germ cell tumorsen
dc.typeArticleen
dc.contributor.departmentMedical College of Wisconsin, MilwaukeeUniversity of Miami Miller School of Medicine/Jackson Health System, Miami, FLen
dc.identifier.journalAmerican Journal of Clinical Pathologyen
dc.description.noteen]


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