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dc.contributor.authorWardhani, LO
dc.contributor.authorMatsushita, M
dc.contributor.authorKuwamoto, S
dc.contributor.authorNonaka, Daisuke
dc.contributor.authorNagata, K
dc.contributor.authorKato, M
dc.contributor.authorKitamura, Y
dc.contributor.authorHayashi, K
dc.date.accessioned2019-02-08T15:20:08Z
dc.date.available2019-02-08T15:20:08Z
dc.date.issued2019en
dc.identifier.citationWardhani LO, Matsushita M, Kuwamoto S, Nonaka D, Nagata K, Kato M, et al. Expression of Notch 3 and Jagged 1is associated with merkel cell polyomavirus status and prognosis in merkel cell carcinoma. Anticancer Res. 2018;39(1):319-29.en
dc.identifier.pmid30591475en
dc.identifier.doi10.21873/anticanres.13114en
dc.identifier.urihttp://hdl.handle.net/10541/621523
dc.description.abstractAIM: Merkel cell carcinoma (MCC) is a rare, aggressive, neuroendocrine skin cancer and most MCCs are related to infection with Merkel cell polyomavirus (MCPyV). Notch signaling modulates cell fate in various tissues including the skin during development and homeostasis, and its aberrant activity relates to onset and progression of various malignancies. Therefore, association of NOTCH1/ NOTCH2/NOTCH3/jagged 1 (JAG1) expression with MCPyV status and prognosis in MCC was investigated. MATERIALS AND METHODS: A total of 19 MCPyV-positive and 19 MCPyV-negative MCC samples from patients were stained immunohistochemically with antibodies against NOTCH1, NOTCH2, NOTCH3, and JAG1 and analyzed. RESULTS: Expression of NOTCH1 and NOTCH2 was not associated with MCPyV status or prognosis. However, higher JAG1 expression was found in MCPyV-negative than in MCPyV-positive MCC (p<0.001), and NOTCH3 expression was higher in MCPyV-positive MCC (p=0.062). Kaplan-Meier and multivariate analyses showed that patients with MCC with higher NOTCH3 expression had better overall survival than otherwise (p=0.001 and p=0.033, respectively). CONCLUSION: Expression of NOTCH3, as a tumor suppressor, is an independent predictor of MCC outcome.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.21873/anticanres.13114en
dc.titleExpression of Notch 3 and Jagged 1 is associated with merkel cell polyomavirus status and prognosis in merkel cell carcinomaen
dc.typeArticleen
dc.contributor.departmentDivision of Molecular Pathology, Department of Pathology, Tottori University Faculty of Medicine, Yonago, Japanen
dc.identifier.journalAnticancer Researchen
dc.description.noteen]


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