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    Expression of Notch 3 and Jagged 1 is associated with merkel cell polyomavirus status and prognosis in merkel cell carcinoma

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    Authors
    Wardhani, LO
    Matsushita, M
    Kuwamoto, S
    Nonaka, Daisuke
    Nagata, K
    Kato, M
    Kitamura, Y
    Hayashi, K
    Affiliation
    Division of Molecular Pathology, Department of Pathology, Tottori University Faculty of Medicine, Yonago, Japan
    Issue Date
    2019
    
    Metadata
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    Abstract
    AIM: Merkel cell carcinoma (MCC) is a rare, aggressive, neuroendocrine skin cancer and most MCCs are related to infection with Merkel cell polyomavirus (MCPyV). Notch signaling modulates cell fate in various tissues including the skin during development and homeostasis, and its aberrant activity relates to onset and progression of various malignancies. Therefore, association of NOTCH1/ NOTCH2/NOTCH3/jagged 1 (JAG1) expression with MCPyV status and prognosis in MCC was investigated. MATERIALS AND METHODS: A total of 19 MCPyV-positive and 19 MCPyV-negative MCC samples from patients were stained immunohistochemically with antibodies against NOTCH1, NOTCH2, NOTCH3, and JAG1 and analyzed. RESULTS: Expression of NOTCH1 and NOTCH2 was not associated with MCPyV status or prognosis. However, higher JAG1 expression was found in MCPyV-negative than in MCPyV-positive MCC (p<0.001), and NOTCH3 expression was higher in MCPyV-positive MCC (p=0.062). Kaplan-Meier and multivariate analyses showed that patients with MCC with higher NOTCH3 expression had better overall survival than otherwise (p=0.001 and p=0.033, respectively). CONCLUSION: Expression of NOTCH3, as a tumor suppressor, is an independent predictor of MCC outcome.
    Citation
    Wardhani LO, Matsushita M, Kuwamoto S, Nonaka D, Nagata K, Kato M, et al. Expression of Notch 3 and Jagged 1is associated with merkel cell polyomavirus status and prognosis in merkel cell carcinoma. Anticancer Res. 2018;39(1):319-29.
    Journal
    Anticancer Research
    URI
    http://hdl.handle.net/10541/621523
    DOI
    10.21873/anticanres.13114
    PubMed ID
    30591475
    Additional Links
    https://dx.doi.org/10.21873/anticanres.13114
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.21873/anticanres.13114
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