Prognostic and predictive biomarkers for somatostatin analogs, peptide receptor radionuclide therapy and serotonin pathway targets in neuroendocrine tumours
Authors
Barriuso, JorgeCustodio, A
Afonso, R
Alonso, V
Astudillo, A
Capdevila, J
Garcia-Carbonero, R
Grande, E
Jimenez-Fonseca, P
Marazuela, M
Rodriguez-Antona, C
Aller, J
Affiliation
Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, The Christie ENETS Centre of ExcellenceIssue Date
2018
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Show full item recordAbstract
Neuroendocrine tumours (NETs) are a heterogeneous group of neoplasms regarding their molecular biology, clinical behaviour, prognosis and response to therapy. Several attempts to establish robust predictive biomarkers have failed. Neither tissue markers nor blood borne ones have proven to be successful yet. Circulating tumour cells (CTCs) as "liquid biopsies" could provide prognostic information at the time a therapeutic decision needs to be made and could be an attractive tool for tumour monitoring throughout the treatment period. However, "liquid biopsies" are far from becoming the standard biomarker in NETs. Promising results have been presented over the last few years using a novel biomarker candidate, a multianalyte algorithm analysis PCR-based test (NETest). New technologies will open the field to different ways of approaching the biomarker conundrum in NETs. However, the complications derived from being a heterogeneous group of malignancies will remain with us forever. In summary, there is an unmet need to incorporate new biomarker candidates into clinical research trials to obtain a robust prospective validation under the most demanding scenario.Citation
Barriuso J, Custodio A, Afonso R, Alonso V, Astudillo A, Capdevila J, et al. Prognostic and predictive biomarkers for somatostatin analogs, peptide receptor radionuclide therapy and serotonin pathway targets in neuroendocrine tumours. Cancer Treat Rev. 2018 Nov;70:209-22.Journal
Cancer Treatment ReviewsDOI
10.1016/j.ctrv.2018.09.008PubMed ID
30292979Additional Links
https://dx.doi.org/10.1016/j.ctrv.2018.09.008Type
ArticleLanguage
enae974a485f413a2113503eed53cd6c53
10.1016/j.ctrv.2018.09.008
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