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dc.contributor.authorBarros-Silva, Jaoa D
dc.contributor.authorLinn, D
dc.contributor.authorSteiner, I
dc.contributor.authorGuo, G
dc.contributor.authorAli, Adnan
dc.contributor.authorPakula, H
dc.contributor.authorAshton, Garry
dc.contributor.authorPeset, I
dc.contributor.authorBrown, Michael D
dc.contributor.authorClarke, Noel W
dc.contributor.authorBronson, R
dc.contributor.authorYuan, G
dc.contributor.authorOrkin, S
dc.contributor.authorLi, Z
dc.contributor.authorBaena, Esther
dc.date.accessioned2019-02-08T15:20:05Z
dc.date.available2019-02-08T15:20:05Z
dc.date.issued2018en
dc.identifier.citationBarros-Silva JD, Linn DE, Steiner I, Guo G, Ali A, Pakula H, et al. Single-cell analysis identifies LY6D as a marker linking castration-resistant prostate luminal cells to prostate progenitors and cancer. Cell Rep. 2018 Dec 18;25(12):3504-18 e6.en
dc.identifier.pmid30566873en
dc.identifier.doi10.1016/j.celrep.2018.11.069en
dc.identifier.urihttp://hdl.handle.net/10541/621503
dc.description.abstractThe exact identity of castrate-resistant (CR) cells and their relation to CR prostate cancer (CRPC) is unresolved. We use single-cell gene profiling to analyze the molecular heterogeneity in basal and luminal compartments. Within the luminal compartment, we identify a subset of cells intrinsically resistant to castration with a bi-lineage gene expression pattern. We discover LY6D as a marker of CR prostate progenitors with multipotent differentiation and enriched organoid-forming capacity. Lineage tracing further reveals that LY6D+ CR luminal cells can produce LY6D- luminal cells. In contrast, in luminal cells lacking PTEN, LY6D+ cells predominantly give rise to LY6D+ tumor cells, contributing to high-grade PIN lesions. Gene expression analyses in patients' biopsies indicate that LY6D expression correlates with early disease progression, including progression to CRPC. Our studies thus identify a subpopulation of luminal progenitors characterized by LY6D expression and intrinsic castration resistance. LY6D may serve as a prognostic maker for advanced prostate cancer.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1016/j.celrep.2018.11.069en
dc.titleSingle-cell analysis identifies LY6D as a marker linking castration-resistant prostate luminal cells to prostate progenitors and canceren
dc.typeArticleen
dc.contributor.departmentProstate Oncobiology, Cancer Research UK Manchester Institute, The University of Manchester, Alderley Park SK10 4TG, UKen
dc.identifier.journalCell Reportsen
dc.description.noteen]


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