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    One-to-one registration of en-face optical coherence tomography attenuation coefficients with histology of a prostatectomy specimen

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    Authors
    Swaan, A
    Muller, BG
    Wilk, LS
    Almasian, M
    van Kollenburg, RAA
    Zwartkruis, E
    Rozendaal, LR
    de Bruin, DM
    Faber, DJ
    van Leeuwen, TG
    van Herk, Marcel
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    Affiliation
    Department of Urology, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands
    Issue Date
    2018
    
    Metadata
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    Abstract
    Optical coherence tomography (OCT), enables high-resolution 3D imaging of the morphology of light scattering tissues. From the OCT signal, parameters can be extracted and related to tissue structures. One of the quantitative parameters is the attenuation coefficient; the rate at which the intensity of detected light decays in depth. To couple the quantitative parameters with the histology one-to-one registration is needed. The primary aim of this study is to validate a registration method of quantitative OCT parameters to histological tissue outcome through one-to-one registration of OCT with histology. We matched OCT images of unstained fixated prostate tissue slices with corresponding histology slides, wherein different histologic types were demarcated. Attenuation coefficients were determined by a supervised automated exponential fit (corrected for point spread function and sensitivity roll-off related signal losses) over a depth of 0.32?mm starting from 0.10 mm below the automatically detected tissue edge. Finally, the attenuation coefficients corresponding to the different tissue types of the prostate were compared. From the attenuation coefficients, we produced the squared relative residue and goodness-of-fit metric R2 . This article explains the method to perform supervised automated quantitative analysis of OCT data, and the one-to-one registration of OCT extracted quantitative data with histopathological outcomes.
    Citation
    Swaan A, Muller BG, Wilk LS, Almasian M, van Kollenburg RAA, Zwartkruis E, et al. One-to-one registration of en-face optical coherence tomography attenuation coefficients with histology of a prostatectomy specimen. J biophotonics. 2018 Nov 22:e201800274.
    Journal
    Journal of Biophotonics
    URI
    http://hdl.handle.net/10541/621490
    DOI
    10.1002/jbio.201800274
    PubMed ID
    30565879
    Additional Links
    https://dx.doi.org/10.1002/jbio.201800274
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1002/jbio.201800274
    Scopus Count
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    All Paterson Institute for Cancer Research

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