Feasibility of using optical coherence tomography to detect radiation-induced fibrosis and residual cancer extent after neoadjuvant chemo-radiation therapy: an ex vivo study
van, Laarhoven, HWM
van Berge, Henegouwen MI
van Leeuwen, TG
de Boer, JF
van Herk, Marcel
AffiliationDepartment of Biomedical Engineering and Physics, Amsterdam UMC, University of Amsterdam, Amsterdam 1105 AZ, The Netherlands
MetadataShow full item record
AbstractTreatment of resectable esophageal cancer includes neoadjuvant chemo-radiation therapy (nCRT) followed by esophagectomy in operable patients. High-risk surgery may have been avoided in patients with a pathological complete response (pCR). We investigated the feasibility of optical coherence tomography (OCT) to detect residual cancer and radiation-induced fibrosis in 10 esophageal cancer patients that underwent nCRT followed by esophagectomy. We compared our OCT findings with histopathology. Overall, OCT was able to differentiate between healthy tissue, fibrotic tissue, and residual cancer with a sensitivity and specificity of 79% and 67%, respectively. Hence, OCT has the potential to add to the assessment of a pCR.
CitationJelvehgaran P, Alderliesten T, Georgiou G, Meijer SL, Bloemen PR, Kodach LL, et al. Feasibility of using optical coherence tomography to detect radiation-induced fibrosis and residual cancer extent after neoadjuvant chemo-radiation therapy: an ex vivo study. Biomed Opt Express. 2018 Sep 1;9(9):4196-216.
JournalBiomedical Optics Express
- Feasibility of using optical coherence tomography to detect acute radiation-induced esophageal damage in small animal models.
- Authors: Jelvehgaran P, de Bruin DM, Salguero FJ, Borst GR, Song JY, van Leeuwen TG, de Boer JF, Alderliesten T, van Herk M
- Issue date: 2018 Apr
- Optical coherence tomography to detect acute esophageal radiation-induced damage in mice: A validation study.
- Authors: Jelvehgaran P, de Bruin DM, Khmelinskii A, Borst G, Steinberg JD, Song JY, de Vos J, van Leeuwen TG, Alderliesten T, de Boer JF, van Herk M
- Issue date: 2019 Sep
- Preoperative chemo-radiation-induced ulceration in patients with esophageal cancer: a confounding factor in tumor response assessment in integrated computed tomographic-positron emission tomographic imaging.
- Authors: Erasmus JJ, Munden RF, Truong MT, Ho JJ, Hofstetter WL, Macapinlac HA, Correa AM, Wu TT, Bruzzi JF, Marom EM, Sabloff BS, Ajani JA, Komaki R, Liao Z, Lee JH, Fukami N, Bresalier R, Swisher SG
- Issue date: 2006 Jun
- Accuracy of Detecting Residual Disease After Cross Neoadjuvant Chemoradiotherapy for Esophageal Cancer (preSANO Trial): Rationale and Protocol.
- Authors: Noordman BJ, Shapiro J, Spaander MC, Krishnadath KK, van Laarhoven HW, van Berge Henegouwen MI, Nieuwenhuijzen GA, van Hillegersberg R, Sosef MN, Steyerberg EW, Wijnhoven BP, van Lanschot JJ, SANO study group.
- Issue date: 2015 Jun 29
- Active surveillance in clinically complete responders after neoadjuvant chemoradiotherapy for esophageal or junctional cancer.
- Authors: Noordman BJ, Wijnhoven BPL, Lagarde SM, Biermann K, van der Gaast A, Spaander MCW, Valkema R, van Lanschot JJB
- Issue date: 2017 Dec 1