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dc.contributor.authorTrucco, Lucas D
dc.contributor.authorMundra, Piyushkumar A
dc.contributor.authorHogan, Kate
dc.contributor.authorGarcia-Martinez, Pablo
dc.contributor.authorViros, Amaya
dc.contributor.authorMandal, Amit Kumar
dc.contributor.authorMacagno, N
dc.contributor.authorGaudy-Marqueste, C
dc.contributor.authorAllan, D
dc.contributor.authorBaenke, Franziska
dc.contributor.authorCook, Martin G
dc.contributor.authorMcManus, Clare
dc.contributor.authorSanchez-Laorden, Berta
dc.contributor.authorDhomen, Nathalie
dc.contributor.authorMarais, Richard
dc.date.accessioned2019-01-10T13:02:07Z
dc.date.available2019-01-10T13:02:07Z
dc.date.issued2018en
dc.identifier.citationTrucco LD, Mundra PA, Hogan K, Garcia-Martinez P, Viros A, Mandal AK, et al. Ultraviolet radiation-induced DNA damage is prognostic for outcome in melanoma. Nat Med. 2018 Dec 3.en
dc.identifier.pmid30510256en
dc.identifier.doi10.1038/s41591-018-0265-6en
dc.identifier.urihttp://hdl.handle.net/10541/621472
dc.description.abstractErratum in Publisher Correction: Ultraviolet radiation-induced DNA damage is prognostic for outcome in melanoma. [Nat Med. 2018] Abstract The melanoma genome is dominated by ultraviolet radiation (UVR)-induced mutations. Their relevance in disease progression is unknown. Here we classify melanomas by mutation signatures and identify ten recurrently mutated UVR signature genes that predict patient survival. We validate these findings in primary human melanomas; in mice we show that this signature is imprinted by short-wavelength UVR and that four exposures to UVR are sufficient to accelerate melanomagenesis.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1038/s41591-018-0265-6en
dc.titleUltraviolet radiation-induced DNA damage is prognostic for outcome in melanoma.en
dc.typeArticleen
dc.contributor.departmentMolecular Oncology Group, Cancer Research UK Manchester Institute, University of Manchester, Manchester, UKen
dc.identifier.journalNature Medicineen
dc.description.noteen]


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