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    Ultraviolet radiation-induced DNA damage is prognostic for outcome in melanoma.

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    Authors
    Trucco, Lucas D
    Mundra, Piyushkumar A
    Hogan, Kate
    Garcia-Martinez, Pablo
    Viros, Amaya
    Mandal, Amit Kumar
    Macagno, N
    Gaudy-Marqueste, C
    Allan, D
    Baenke, Franziska
    Cook, Martin G
    McManus, Clare
    Sanchez-Laorden, Berta
    Dhomen, Nathalie
    Marais, Richard
    Show allShow less
    Affiliation
    Molecular Oncology Group, Cancer Research UK Manchester Institute, University of Manchester, Manchester, UK
    Issue Date
    2018
    
    Metadata
    Show full item record
    Abstract
    Erratum in Publisher Correction: Ultraviolet radiation-induced DNA damage is prognostic for outcome in melanoma. [Nat Med. 2018] Abstract The melanoma genome is dominated by ultraviolet radiation (UVR)-induced mutations. Their relevance in disease progression is unknown. Here we classify melanomas by mutation signatures and identify ten recurrently mutated UVR signature genes that predict patient survival. We validate these findings in primary human melanomas; in mice we show that this signature is imprinted by short-wavelength UVR and that four exposures to UVR are sufficient to accelerate melanomagenesis.
    Citation
    Trucco LD, Mundra PA, Hogan K, Garcia-Martinez P, Viros A, Mandal AK, et al. Ultraviolet radiation-induced DNA damage is prognostic for outcome in melanoma. Nat Med. 2018 Dec 3.
    Journal
    Nature Medicine
    URI
    http://hdl.handle.net/10541/621472
    DOI
    10.1038/s41591-018-0265-6
    PubMed ID
    30510256
    Additional Links
    https://dx.doi.org/10.1038/s41591-018-0265-6
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1038/s41591-018-0265-6
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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