Ultraviolet radiation-induced DNA damage is prognostic for outcome in melanoma.
AuthorsTrucco, Lucas D
Mundra, Piyushkumar A
Mandal, Amit Kumar
Cook, Martin G
AffiliationMolecular Oncology Group, Cancer Research UK Manchester Institute, University of Manchester, Manchester, UK
MetadataShow full item record
AbstractErratum in Publisher Correction: Ultraviolet radiation-induced DNA damage is prognostic for outcome in melanoma. [Nat Med. 2018] Abstract The melanoma genome is dominated by ultraviolet radiation (UVR)-induced mutations. Their relevance in disease progression is unknown. Here we classify melanomas by mutation signatures and identify ten recurrently mutated UVR signature genes that predict patient survival. We validate these findings in primary human melanomas; in mice we show that this signature is imprinted by short-wavelength UVR and that four exposures to UVR are sufficient to accelerate melanomagenesis.
CitationTrucco LD, Mundra PA, Hogan K, Garcia-Martinez P, Viros A, Mandal AK, et al. Ultraviolet radiation-induced DNA damage is prognostic for outcome in melanoma. Nat Med. 2018 Dec 3.
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