Ultraviolet radiation-induced DNA damage is prognostic for outcome in melanoma.
Authors
Trucco, Lucas DMundra, Piyushkumar A
Hogan, Kate
Garcia-Martinez, Pablo
Viros, Amaya
Mandal, Amit Kumar
Macagno, N
Gaudy-Marqueste, C
Allan, D
Baenke, Franziska
Cook, Martin G
McManus, Clare
Sanchez-Laorden, Berta
Dhomen, Nathalie
Marais, Richard
Affiliation
Molecular Oncology Group, Cancer Research UK Manchester Institute, University of Manchester, Manchester, UKIssue Date
2018
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Show full item recordAbstract
Erratum in Publisher Correction: Ultraviolet radiation-induced DNA damage is prognostic for outcome in melanoma. [Nat Med. 2018] Abstract The melanoma genome is dominated by ultraviolet radiation (UVR)-induced mutations. Their relevance in disease progression is unknown. Here we classify melanomas by mutation signatures and identify ten recurrently mutated UVR signature genes that predict patient survival. We validate these findings in primary human melanomas; in mice we show that this signature is imprinted by short-wavelength UVR and that four exposures to UVR are sufficient to accelerate melanomagenesis.Citation
Trucco LD, Mundra PA, Hogan K, Garcia-Martinez P, Viros A, Mandal AK, et al. Ultraviolet radiation-induced DNA damage is prognostic for outcome in melanoma. Nat Med. 2018 Dec 3.Journal
Nature MedicineDOI
10.1038/s41591-018-0265-6PubMed ID
30510256Additional Links
https://dx.doi.org/10.1038/s41591-018-0265-6Type
ArticleLanguage
enae974a485f413a2113503eed53cd6c53
10.1038/s41591-018-0265-6
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