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dc.contributor.authorJeon, YJ
dc.contributor.authorKim, T
dc.contributor.authorPark, D
dc.contributor.authorNuovo, GJ
dc.contributor.authorRhee, S
dc.contributor.authorJoshi, P
dc.contributor.authorLee, BK
dc.contributor.authorJeong, J
dc.contributor.authorSuh, SS
dc.contributor.authorGrotzke, JE
dc.contributor.authorKim, SH
dc.contributor.authorSong, J
dc.contributor.authorSim, H
dc.contributor.authorKim, Y
dc.contributor.authorPeng, Y
dc.contributor.authorJeong, Y
dc.contributor.authorGarofalo, Michela
dc.contributor.authorZanesi, N
dc.contributor.authorKim, J
dc.contributor.authorLiang, G
dc.contributor.authorNakano, I
dc.contributor.authorCresswell, P
dc.contributor.authorNana-Sinkam, P
dc.contributor.authorCui, R
dc.contributor.authorCroce, CM
dc.date.accessioned2019-01-10T13:02:07Z
dc.date.available2019-01-10T13:02:07Z
dc.date.issued2018en
dc.identifier.citationJeon YJ, Kim T, Park D, Nuovo GJ, Rhee S, Joshi P, et al. miRNA-mediated TUSC3 deficiency enhances UPR and ERAD to promote metastatic potential of NSCLC. Nat Commun. 2018 Nov 30;9(1):5110.en
dc.identifier.pmid30504895en
dc.identifier.doi10.1038/s41467-018-07561-8en
dc.identifier.urihttp://hdl.handle.net/10541/621471
dc.description.abstractNon-small cell lung carcinoma (NSCLC) is leading cause of cancer-related deaths in the world. The Tumor Suppressor Candidate 3 (TUSC3) at chromosome 8p22 known to be frequently deleted in cancer is often found to be deleted in advanced stage of solid tumors. However, the role of TUSC3 still remains controversial in lung cancer and context-dependent in several cancers. Here we propose that miR-224/-520c-dependent TUSC3 deficiency enhances the metastatic potential of NSCLC through the alteration of three unfolded protein response pathways and HRD1-dependent ERAD. ATF6?-dependent UPR is enhanced whereas the affinity of HRD1 to its substrates, PERK, IRE1? and p53 is weakened. Consequently, the alteration of UPRs and the suppressed p53-NM23H1/2 pathway by TUSC3 deficiency is ultimately responsible for enhancing metastatic potential of lung cancer. These findings provide mechanistic insight of unrecognized roles of TUSC3 in cancer progression and the oncogenic role of HRD1-dependent ERAD in cancer metastasis.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1038/s41467-018-07561-8en
dc.titlemiRNA-mediated TUSC3 deficiency enhances UPR and ERAD to promote metastatic potential of NSCLC.en
dc.typeArticleen
dc.contributor.departmentComprehensive Cancer Center, The Ohio State University, Columbus, OH, 43210, USAen
dc.identifier.journalNature Communicationsen
dc.description.noteen]
refterms.dateFOA2020-04-22T13:04:57Z


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