Electrochemotherapy - emerging applications technical advances, new indications, combined approaches, and multi-institutional collaboration.
AffiliationDepartment of Surgery Oncology and Gastroenterology (DISCOG), University of Padua, Italy
MetadataShow full item record
AbstractThe treatment of tumors with electrochemotherapy (ECT) has surged over the past decade. Thanks to the transient cell membrane permeabilization induced by the short electric pulses used by ECT, cancer cells are exposed to otherwise poorly permeant chemotherapy agents, with consequent increased cytotoxicity. The codification of the procedure in 2006 led to a broad diffusion of the procedure, mainly in Europe, and since then, the progressive clinical experience, together with the emerging technologies, have extended the range of its application. Herein, we review the key advances in the ECT field since the European Standard Operating Procedures on ECT (ESOPE) 2006 guidelines and discuss the emerging clinical data on the new ECT indications. First, technical developments have improved ECT equipment, with custom electrode probes and dedicated tools supporting individual treatment planning in anatomically challenging tumors. Second, the feasibility and short-term efficacy of ECT has been established in deep-seated tumors, including bone metastases, liver malignancies, and pancreatic and prostate cancers (long-needle variable electrode geometry ECT), and gastrointestinal tumors (endoscopic ECT). Moreover, pioneering studies indicate lung and brain tumors as suitable future targets. A further advance relates to new combination strategies with immunotherapy, gene electro transfer (GET), calcium EP, and radiotherapy. Finally and fourth, cross-institutional collaborative groups have been established to refine procedural guidelines, promote clinical research, and explore new indications.
CitationCampana L, Edhemovic I, Soden D, Perrone A, Scarpa M, Campanacci L, et al. Electrochemotherapy - emerging applications technical advances, new indications, combined approaches, and multi-institutional collaboration. Eur J Surg Oncol. 2018 Dec 1.
JournalEur J Surg Oncol
- Electrochemotherapy a novel approach to the treatment of metastatic nodules on the skin and subcutaneous tissues.
- Authors: Giardino R, Fini M, Bonazzi V, Cadossi R, Nicolini A, Carpi A
- Issue date: 2006 Sep
- Treatment efficacy with electrochemotherapy: A multi-institutional prospective observational study on 376 patients with superficial tumors.
- Authors: Campana LG, Testori A, Curatolo P, Quaglino P, Mocellin S, Framarini M, Borgognoni L, Ascierto PA, Mozzillo N, Guida M, Bucher S, Rotunno R, Marenco F, De Salvo GL, De Paoli A, Rossi CR, Bonadies A
- Issue date: 2016 Dec
- Electrochemotherapy of solid tumors--preclinical and clinical experience.
- Authors: Sersa G, Cemazar M, Snoj M
- Issue date: 2011
- Utility of electrochemotherapy in melanoma treatment.
- Authors: Testori A, Rossi CR, Tosti G
- Issue date: 2012 Mar
- [Electrochemotherapy: mechanism of action and clinical results in the locoregional treatment of patients with skin cancers and superficial metastases].
- Authors: Campana LG, Marconato R, Sieni E, Valpione S, Corti L, Mocellin S, Rossi CR
- Issue date: 2016 Aug