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dc.contributor.authorHadjidemetriou, M
dc.contributor.authorMcAdam, Sarah
dc.contributor.authorGarner, Grace
dc.contributor.authorThackeray, Chelsey
dc.contributor.authorKnight, D
dc.contributor.authorSmith, Duncan L
dc.contributor.authorAl-Ahmady, Z
dc.contributor.authorMazza, M
dc.contributor.authorRogan, Jane
dc.contributor.authorClamp, Andrew R
dc.contributor.authorKostarelos, K
dc.date.accessioned2019-01-10T13:02:03Z
dc.date.available2019-01-10T13:02:03Z
dc.date.issued2018en
dc.identifier.citationHadjidemetriou M, McAdam S, Garner G, Thackeray C, Knight D, Smith D, et al. The human in vivo biomolecule corona onto pegylated liposomes: a proof-of-concept clinical study. Adv Mater. 2018 Nov 28:e1803335.en
dc.identifier.pmid30488990en
dc.identifier.doi10.1002/adma.201803335en
dc.identifier.urihttp://hdl.handle.net/10541/621449
dc.description.abstractThe self-assembled layered adsorption of proteins onto nanoparticle (NP) surfaces, once in contact with biological fluids, is termed the "protein corona" and it is gradually seen as a determinant factor for the overall biological behavior of NPs. Here, the previously unreported in vivo protein corona formed in human systemic circulation is described. The human-derived protein corona formed onto PEGylated doxorubicin-encapsulated liposomes (Caelyx) is thoroughly characterized following the recovery of liposomes from the blood circulation of ovarian carcinoma patients. In agreement with previous investigations in mice, the in vivo corona is found to be molecularly richer in comparison to its counterpart ex vivo corona. The intravenously infused liposomes are able to scavenge the blood pool and surface-capture low-molecular-weight, low-abundance plasma proteins that cannot be detected by conventional plasma proteomic analysis. This study describes the previously elusive or postulated formation of protein corona around nanoparticles in vivo in humans and illustrates that it can potentially be used as a novel tool to analyze the blood circulation proteome.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1002/adma.201803335en
dc.titleThe human in vivo biomolecule corona onto PEGylated Liposomes: a proof-of-concept clinical study.en
dc.typeArticleen
dc.contributor.departmentNanomedicine Lab, Faculty of Biology, Medicine and Health, The University of Manchester, AV Hill Building, Manchester, M13 9PT, UKen
dc.identifier.journalAdv Materen
dc.description.noteen]


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