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    The human in vivo biomolecule corona onto PEGylated Liposomes: a proof-of-concept clinical study.

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    Authors
    Hadjidemetriou, M
    McAdam, Sarah
    Garner, Grace
    Thackeray, Chelsey
    Knight, D
    Smith, Duncan L
    Al-Ahmady, Z
    Mazza, M
    Rogan, Jane
    Clamp, Andrew R
    Kostarelos, K
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    Affiliation
    Nanomedicine Lab, Faculty of Biology, Medicine and Health, The University of Manchester, AV Hill Building, Manchester, M13 9PT, UK
    Issue Date
    2018
    
    Metadata
    Show full item record
    Abstract
    The self-assembled layered adsorption of proteins onto nanoparticle (NP) surfaces, once in contact with biological fluids, is termed the "protein corona" and it is gradually seen as a determinant factor for the overall biological behavior of NPs. Here, the previously unreported in vivo protein corona formed in human systemic circulation is described. The human-derived protein corona formed onto PEGylated doxorubicin-encapsulated liposomes (Caelyx) is thoroughly characterized following the recovery of liposomes from the blood circulation of ovarian carcinoma patients. In agreement with previous investigations in mice, the in vivo corona is found to be molecularly richer in comparison to its counterpart ex vivo corona. The intravenously infused liposomes are able to scavenge the blood pool and surface-capture low-molecular-weight, low-abundance plasma proteins that cannot be detected by conventional plasma proteomic analysis. This study describes the previously elusive or postulated formation of protein corona around nanoparticles in vivo in humans and illustrates that it can potentially be used as a novel tool to analyze the blood circulation proteome.
    Citation
    Hadjidemetriou M, McAdam S, Garner G, Thackeray C, Knight D, Smith D, et al. The human in vivo biomolecule corona onto pegylated liposomes: a proof-of-concept clinical study. Adv Mater. 2018 Nov 28:e1803335.
    Journal
    Adv Mater
    URI
    http://hdl.handle.net/10541/621449
    DOI
    10.1002/adma.201803335
    PubMed ID
    30488990
    Additional Links
    https://dx.doi.org/10.1002/adma.201803335
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1002/adma.201803335
    Scopus Count
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