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dc.contributor.authorHague, Christina
dc.contributor.authorBeasley, William J
dc.contributor.authorDixon, Lynne
dc.contributor.authorGaito, Simona
dc.contributor.authorGarcez, Kate
dc.contributor.authorGreen, Andrew
dc.contributor.authorLee, Lip W
dc.contributor.authorMaranzano, M
dc.contributor.authorMcPartlin, Andrew J
dc.contributor.authorMistry, Hitesh
dc.contributor.authorMullan, Damian
dc.contributor.authorSykes, Andrew J
dc.contributor.authorThomson, David J
dc.contributor.authorvan Herk, Marcel
dc.contributor.authorWest, Catharine ML
dc.contributor.authorSlevin, Nicholas J
dc.date.accessioned2018-12-10T11:48:54Z
dc.date.available2018-12-10T11:48:54Z
dc.date.issued2018en
dc.identifier.citationHague C, Beasley W, Dixon L, Gaito S, Garcez K, Green A, et al. Use of a novel atlas for muscles of mastication to reduce inter observer variability in head and neck radiotherapy contouring. Radiother Oncol. 2018 Nov 9.en
dc.identifier.pmid30420234en
dc.identifier.doi10.1016/j.radonc.2018.10.030en
dc.identifier.urihttp://hdl.handle.net/10541/621409
dc.description.abstractPURPOSE/OBJECTIVE(S): Trismus is caused by injury to the masticatory muscles resulting from cancer or its treatment. Contouring these muscles to reduce dose and radiation related trismus can be problematic due to interobserver variability. This study aimed to evaluate the reduction in interobserver variability achievable with a new contouring atlas. MATERIALS/METHODS: The atlas included: medial and lateral pterygoids (MP, LP), masseter (M) and temporalis (T) muscles, and the temporo-mandibular joint (TMJ). Seven clinicians delineated five paired structures on CT scans from 5 patients without the atlas. After ?5?weeks, contouring was repeated using the atlas. Using contours generated by the clinicians on the same 5 CT scans as reference, dice similarity coefficient (DSC), mean distance-to-agreement (DTA) and centre of mass (COM) difference were compared with and without the atlas. Comparison was also performed split by training grade. Mean and standard deviation (SD) values were measured. RESULTS: The atlas reduced interobserver variability for all structures. Mean DTA significantly improved for MP (p?=?0.01), M (p?<?0.01), T (p?<?0.01) and TMJ (p?<?0.01). Mean DTA improved using the atlas for the trainees across all muscles, with the largest reduction in variability observed for the T (4.3?±?7.1 v 1.2?±?0.4?mm, p?=?0.06) and TMJ (2.1?±?0.7 v 0.8?±?0.3?mm, p?<?0.01). Distance between the COM and interobserver variability reduced in all directions for MP and T. CONCLUSION: A new atlas for contouring masticatory muscles during radiotherapy planning for head and neck cancer reduces interobserver variability and could be used as an educational tool.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1016/j.radonc.2018.10.030en
dc.titleUse of a novel atlas for muscles of mastication to reduce inter observer variability in head and neck radiotherapy contouring.en
dc.typeArticleen
dc.contributor.departmentDepartment of Head and Neck Clinical Oncology, The Christie NHS Foundation Trust, Manchester, UKen
dc.identifier.journalRadiotherapy and Oncologyen
refterms.dateFOA2019-01-03T14:27:13Z


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