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dc.contributor.authorJones, DK
dc.contributor.authorAlexander, DC
dc.contributor.authorBowtell, R
dc.contributor.authorCercignani, M
dc.contributor.authorDell'Acqua, F
dc.contributor.authorMcHugh, Damien J
dc.contributor.authorMiller, KL
dc.contributor.authorPalombo, M
dc.contributor.authorParker, Geoff JM
dc.contributor.authorRudrapatna, US
dc.contributor.authorTax, CMW
dc.date.accessioned2018-12-05T10:35:51Z
dc.date.available2018-12-05T10:35:51Z
dc.date.issued2018en
dc.identifier.citationJones DK, Alexander DC, Bowtell R, Cercignani M, Dell'Acqua F, McHugh DJ, et al. Microstructural imaging of the human brain with a �super-scanner�: 10 key advantages of ultra-strong gradients for diffusion MRI. NeuroImage. 2018 Nov;182:8�38.en
dc.identifier.pmid29793061en
dc.identifier.doi10.1016/j.neuroimage.2018.05.047en
dc.identifier.urihttp://hdl.handle.net/10541/621369
dc.description.abstractThe key component of a microstructural diffusion MRI 'super-scanner' is a dedicated high-strength gradient system that enables stronger diffusion weightings per unit time compared to conventional gradient designs. This can, in turn, drastically shorten the time needed for diffusion encoding, increase the signal-to-noise ratio, and facilitate measurements at shorter diffusion times. This review, written from the perspective of the UK National Facility for In Vivo MR Imaging of Human Tissue Microstructure, an initiative to establish a shared 300 mT/m-gradient facility amongst the microstructural imaging community, describes ten advantages of ultra-strong gradients for microstructural imaging. Specifically, we will discuss how the increase of the accessible measurement space compared to a lower-gradient systems (in terms of ?, b-value, and TE) can accelerate developments in the areas of 1) axon diameter distribution mapping; 2) microstructural parameter estimation; 3) mapping micro-vs macroscopic anisotropy features with gradient waveforms beyond a single pair of pulsed-gradients; 4) multi-contrast experiments, e.g. diffusion-relaxometry; 5) tractography and high-resolution imaging in vivo and 6) post mortem; 7) diffusion-weighted spectroscopy of metabolites other than water; 8) tumour characterisation; 9) functional diffusion MRI; and 10) quality enhancement of images acquired on lower-gradient systems. We finally discuss practical barriers in the use of ultra-strong gradients, and provide an outlook on the next generation of 'super-scanners'.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1016/j.neuroimage.2018.05.047en
dc.titleMicrostructural imaging of the human brain with a 'super-scanner': 10 key advantages of ultra-strong gradients for diffusion MRIen
dc.typeArticleen
dc.contributor.departmentCardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Maindy Road, Cardiffen
dc.identifier.journalNeuroimageen
dc.description.noteen]


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