Microstructural imaging of the human brain with a 'super-scanner': 10 key advantages of ultra-strong gradients for diffusion MRI
McHugh, Damien J
Parker, Geoff JM
AffiliationCardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Maindy Road, Cardiff
MetadataShow full item record
AbstractThe key component of a microstructural diffusion MRI 'super-scanner' is a dedicated high-strength gradient system that enables stronger diffusion weightings per unit time compared to conventional gradient designs. This can, in turn, drastically shorten the time needed for diffusion encoding, increase the signal-to-noise ratio, and facilitate measurements at shorter diffusion times. This review, written from the perspective of the UK National Facility for In Vivo MR Imaging of Human Tissue Microstructure, an initiative to establish a shared 300 mT/m-gradient facility amongst the microstructural imaging community, describes ten advantages of ultra-strong gradients for microstructural imaging. Specifically, we will discuss how the increase of the accessible measurement space compared to a lower-gradient systems (in terms of ?, b-value, and TE) can accelerate developments in the areas of 1) axon diameter distribution mapping; 2) microstructural parameter estimation; 3) mapping micro-vs macroscopic anisotropy features with gradient waveforms beyond a single pair of pulsed-gradients; 4) multi-contrast experiments, e.g. diffusion-relaxometry; 5) tractography and high-resolution imaging in vivo and 6) post mortem; 7) diffusion-weighted spectroscopy of metabolites other than water; 8) tumour characterisation; 9) functional diffusion MRI; and 10) quality enhancement of images acquired on lower-gradient systems. We finally discuss practical barriers in the use of ultra-strong gradients, and provide an outlook on the next generation of 'super-scanners'.
CitationJones DK, Alexander DC, Bowtell R, Cercignani M, Dell'Acqua F, McHugh DJ, et al. Microstructural imaging of the human brain with a �super-scanner�: 10 key advantages of ultra-strong gradients for diffusion MRI. NeuroImage. 2018 Nov;182:8�38.
- Validation of diffusion MRI estimates of compartment size and volume fraction in a biomimetic brain phantom using a human MRI scanner with 300 mT/m maximum gradient strength.
- Authors: Fan Q, Nummenmaa A, Wichtmann B, Witzel T, Mekkaoui C, Schneider W, Wald LL, Huang SY
- Issue date: 2018 Nov 15
- Pushing the limits of in vivo diffusion MRI for the Human Connectome Project.
- Authors: Setsompop K, Kimmlingen R, Eberlein E, Witzel T, Cohen-Adad J, McNab JA, Keil B, Tisdall MD, Hoecht P, Dietz P, Cauley SF, Tountcheva V, Matschl V, Lenz VH, Heberlein K, Potthast A, Thein H, Van Horn J, Toga A, Schmitt F, Lehne D, Rosen BR, Wedeen V, Wald LL
- Issue date: 2013 Oct 15
- The impact of gradient strength on in vivo diffusion MRI estimates of axon diameter.
- Authors: Huang SY, Nummenmaa A, Witzel T, Duval T, Cohen-Adad J, Wald LL, McNab JA
- Issue date: 2015 Feb 1
- Post-mortem inference of the human hippocampal connectivity and microstructure using ultra-high field diffusion MRI at 11.7 T.
- Authors: Beaujoin J, Palomero-Gallagher N, Boumezbeur F, Axer M, Bernard J, Poupon F, Schmitz D, Mangin JF, Poupon C
- Issue date: 2018 Jun
- Resolution limit of cylinder diameter estimation by diffusion MRI: The impact of gradient waveform and orientation dispersion.
- Authors: Nilsson M, Lasič S, Drobnjak I, Topgaard D, Westin CF
- Issue date: 2017 Jul