Omega-3 fatty acid supplement skin cancer prophylaxis in lung transplant recipients: A randomized, controlled pilot trial
dc.contributor.author | Miura, K | |
dc.contributor.author | Vail, A | |
dc.contributor.author | Chambers, D | |
dc.contributor.author | Hopkins, PM | |
dc.contributor.author | Ferguson, L | |
dc.contributor.author | Grant, M | |
dc.contributor.author | Rhodes, LE | |
dc.contributor.author | Green, Adèle C | |
dc.date.accessioned | 2018-12-05T10:35:50Z | |
dc.date.available | 2018-12-05T10:35:50Z | |
dc.date.issued | 2018 | en |
dc.identifier.citation | Miura K, Vail A, Chambers D, Hopkins PM, Ferguson L, Grant M, et al. Omega-3 fatty acid supplement skin cancer prophylaxis in lung transplant recipients: A randomized, controlled pilot trial. The Journal of Heart and Lung Transplantation [Internet]. 2018 Sep. | en |
dc.identifier.pmid | 30352778 | en |
dc.identifier.doi | 10.1016/j.healun.2018.09.009 | en |
dc.identifier.uri | http://hdl.handle.net/10541/621365 | |
dc.description.abstract | BACKGROUND: Lung transplant recipients (LTRs) are at very high risk of skin cancer. Omega-3 fatty acids (FAs) are anti-inflammatory and immune-modulating and could potentially reduce this risk. We assessed the feasibility of omega-3 FA supplementation to reduce skin cancer among these patients. METHODS: LTRs aged 18+ years, at least 1 year post-transplant, were recruited from the outpatient clinic of The Prince Charles Hospital, Brisbane. Participants were randomly allocated to 4-times-daily supplements containing either omega-3 FA (3.36 eicosapentaenoic acid [EPA]?+?docosahexaenoic acid) or placebo (4 g olive oil) for 12 months. Primary outcomes were rates of recruitment, retention, adherence (assessed by plasma omega-3 FA), and safety. Secondary outcomes were incident skin cancers. RESULTS: Among 106 eligible lung transplant recipients, 49 consented to take part (46%) with 25 allocated to omega-3 FA and 24 to placebo supplements. Of these, 22 (88%) and 20 (83%), respectively, completed the trial. After 12 months, median plasma EPA increased substantially in the intervention group (125.0 to 340.0 �mol/L), but not the placebo group (98.0 to 134.5 �mol/L). In the intervention group, 6 patients developed skin cancers compared with 11 in the placebo group, giving an odds ratio (95% confidence interval) of 0.34 (0.09 to 1.32). There were no serious, active intervention-related adverse events. CONCLUSIONS: This pilot trial among LTRs showed acceptable recruitment and high retention and adherence. We demonstrated a signal for reduction of new skin cancer cases in those taking omega-3 FA supplements, which supports the notion that a larger, more definitive trial is warranted. | en |
dc.language.iso | en | en |
dc.relation.url | https://dx.doi.org/10.1016/j.healun.2018.09.009 | en |
dc.title | Omega-3 fatty acid supplement skin cancer prophylaxis in lung transplant recipients: A randomized, controlled pilot trial | en |
dc.type | Article | en |
dc.contributor.department | Cancer and Population Studies Group, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia | en |
dc.identifier.journal | J Heart Lung Transplant | en |
dc.description.note | en] |