• Login
    View Item 
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsProfilesView

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    The role of personalized Interventional Radiotherapy (brachytherapy) in the management of older patients with non-melanoma skin cancer

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Lancellotta, V
    Kovacs, G
    Tagliaferri, L
    Perrucci, E
    Rembielak, Agata
    Stingeni, L
    Tramontana, M
    Hansel, K
    Colloca, G
    Saldi, S
    Valentini, V
    Aristei, C
    Show allShow less
    Affiliation
    Radiation Oncology Section, Department of Surgical and Biomedical Science, University of Perugia and Perugia General Hospital, Perugia, Italy
    Issue Date
    2018
    
    Metadata
    Show full item record
    Abstract
    OBJECTIVE: Non-melanoma skin cancer (NMSC) has been rapidly increasing in incidence over the past 30?years. Mainstays of treatment remain surgery and radiotherapy, particularly in older and/or frail patients (?75?years old) that often require a personalized treatment strategy using innovative biotechnologies. High-dose-rate interventional radiotherapy (HDR-IRT) seems to be an excellent option for NMSC. MATERIAL AND METHODS: Nineteen aged patients with advanced, biopsy proven NMSC were treated with exclusively HDR-IRT. A personalized double-layer mould of thermoplastic mask material was applied to the skin surface. Plastic tubes were fixed on the mould in appropriate geometry over the target area. Planning computed tomography (CT) images were acquired with 2.5?mm slice thickness and transmitted to the planning system. Treatment intention was to deliver ?95% of the prescribed dose to the Planning Target Volume (PTV), accepting 90% as satisfactory. Toxicities were assessed using the Common Terminology Criteria for Adverse Events scale (CTCAE) v. 4.0. RESULTS: Median age was 86?years. Acute toxicity: Grade 2 erythema appeared in all 19 patients. Towards the end of each treatment schedule, epidermolysis developed which was resolved within 6?weeks of completing HDR-IRT. Late toxicity: Grade 1 skin atrophy, pigmentation changes and alopecia in field were observed in all patients. At last follow-up, all patients were disease free. CONCLUSIONS: Personalized HDR-IRT appears to be safe and effective for frail older patients and a valid alternative to supportive care for those with contraindication to surgery. Future investigations using also large database analysis seem to be advisory.
    Citation
    Lancellotta V, Kov�cs G, Tagliaferri L, Perrucci E, Rembielak A, Stingeni L, et al. The role of personalized Interventional Radiotherapy (brachytherapy) in the management of older patients with non-melanoma skin cancer. Journal of Geriatric Oncology. 2018 Oct.
    Journal
    J Geriatr Oncol
    URI
    http://hdl.handle.net/10541/621357
    DOI
    10.1016/j.jgo.2018.09.009
    PubMed ID
    30314955
    Additional Links
    https://dx.doi.org/10.1016/j.jgo.2018.09.009
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.jgo.2018.09.009
    Scopus Count
    Collections
    All Christie Publications

    entitlement

    Related articles

    • Clinical and toxicity outcomes with 3D based-HDR surface mold brachytherapy in skin cancer.
    • Authors: Yadavalli P, Pareek V, Barthwal M, Bharat R, Mullassery S, Aashita, Patil P, Sharma A, Sharma DN, Mallick S
    • Issue date: 2024 Apr 1
    • Clinical and cosmetic outcomes in patients treated with high-dose-rate electronic brachytherapy for nonmelanoma skin cancer.
    • Authors: Paravati AJ, Hawkins PG, Martin AN, Mansy G, Rahn DA, Advani SJ, Hoisak J, Dragojevic I, Martin PJ, Miller CJ, Sanghvi P
    • Issue date: 2015 Nov-Dec
    • Hypofractionated high-dose-rate plesiotherapy in nonmelanoma skin cancer treatment.
    • Authors: Arenas M, Arguís M, Díez-Presa L, Henríquez I, Murcia-Mejía M, Gascón M, Gómez D, Lafuerza A, Mur E, Azón A, Rovirosa À, Sabater S
    • Issue date: 2015 Nov-Dec
    • Treatment of skin carcinomas of the face by high-dose-rate brachytherapy and custom-made surface molds.
    • Authors: Guix B, Finestres F, Tello J, Palma C, Martinez A, Guix J, Guix R
    • Issue date: 2000 Apr 1
    • High dose rate brachytherapy with customized applicators for malignant facial skin lesions.
    • Authors: Jumeau R, Renard-Oldrini S, Courrech F, Buchheit I, Oldrini G, Vogin G, Peiffert D
    • Issue date: 2016 Jul
    DSpace software (copyright © 2002 - 2025)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.