Factors affecting local regrowth after watch and wait for patients with a clinical complete response following chemoradiotherapy in rectal cancer (InterCoRe consortium): an individual participant data meta-analysis.

Chadi, S; Malcomson, Lee; Ensor, J; Riley, R; Vaccaro, C; Rossi, G; Daniels, I; Smart, N; Osborne, M; Beets, G; Maas, M; Bitterman, D; Du, K; Gollins, S; Sun Myint, A; Smith, F; Saunders, Mark P; Scott, N; O'Dwyer, Sarah T; de Castro Araujo, R; Valadao, M; Lopes, A; Hsiao, C; Lai, C; Smith, R; Paulson, E; Appelt, A; Jakobsen, A; Wexner, S; Habr-Gama, A; Sao Julião, G; Perez, R; Renehan, Andrew G

Affiliation

Division of Surgical Oncology and General Surgery, Princess Margaret Hospital and University Health Network, University of Toronto, Toronto, ON, Canada

Issue Date

2018-10-11

Metadata

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Abstract

In patients with rectal cancer who achieve clinical complete response after neoadjuvant chemoradiotherapy, watch and wait is a novel management strategy with potential to avoid major surgery. Study-level meta-analyses have reported wide variation in the proportion of patients with local regrowth. We did an individual participant data meta-analysis to investigate factors affecting occurrence of local regrowth.

Citation

Factors affecting local regrowth after watch and wait for patients with a clinical complete response following chemoradiotherapy in rectal cancer (InterCoRe consortium): an individual participant data meta-analysis. 2018 Lancet Gastroenterol Hepatol

Journal

The Lancet. Gastroenterology & Hepatology

URI

http://hdl.handle.net/10541/621332

DOI

10.1016/S2468-1253(18)30301-7

PubMed ID

30318451

Type

Article

Language

ISSN

2468-1253

Collections

All Christie Publications