Computer-based intensity measurement assists pathologists in scoring PTEN immunohistochemistry - clinical associations in NSCLC patients of the ETOP Lungscape cohort.
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Authors
Rulle, UTsourti, Z
Casanova, R
Deml, K
Verbeken, E
Thunnissen, E
Warth, A
Cheney, R
Sejda, A
Speel, E
Madsen, L
Nonaka, Daisuke
Navarro, A
Sansano, I
Marchetti, A
Finn, S
Monkhorst, K
Kerr, K
Haberecker, M
Wu, C
Zygoura, P
Kammler, R
Geiger, T
Gendreau, S
Schulze, K
Vrugt, B
Wild, P
Moch, H
Weder, W
Ciftlik, A
Dafni, U
Peters, S
Bubendorf, L
Stahel, R
Soltermann, A
Affiliation
Institute of Pathology and Molecular Pathology, University Hospital Zurich, 8091 Zurich, SwitzerlandIssue Date
2018-09-18
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Show full item recordAbstract
PTEN loss is frequently observed in NSCLC and associated with both PI3K activation and tumoral immunosuppression. PTEN immunohistochemistry is a valuable read-out, but lacks standardized staining protocol and cut-off value.Citation
Computer-based intensity measurement assists pathologists in scoring PTEN immunohistochemistry - clinical associations in NSCLC patients of the ETOP Lungscape cohort. 2018, J Thorac OncolJournal
Journal of Thoracic OncologyDOI
10.1016/j.jtho.2018.08.2034PubMed ID
30240851Type
ArticleLanguage
enISSN
1556-1380ae974a485f413a2113503eed53cd6c53
10.1016/j.jtho.2018.08.2034
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