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    The role of biomarkers in bladder preservation management of muscle-invasive bladder cancer.

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    Authors
    Mitin, T
    Choudhury, Ananya
    Affiliation
    Department of Radiation Medicine, Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA
    Issue Date
    2018-09-14
    
    Metadata
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    Abstract
    Patients with localized muscle-invasive bladder cancer (MIBC) can choose to undergo either neoadjuvant chemotherapy followed by radical cystectomy or radiation therapy-based bladder preservation treatment modality with subsequent close cystoscopic surveillance with salvage cystectomy reserved for patients with evidence of local disease recurrence. At the present time, the decision regarding bladder-directed local therapy for MIBC is based on physicians' and patients' preferences, and does not take into account tumor biology. Predictive biomarkers, once validated, could offer a more patient-centered and biology-driven selection of bladder-directed therapies.
    Citation
    The role of biomarkers in bladder preservation management of muscle-invasive bladder cancer. 2018, World J Urol
    Journal
    World Journal of Urology
    URI
    http://hdl.handle.net/10541/621305
    DOI
    10.1007/s00345-018-2480-7
    PubMed ID
    30218307
    Type
    Article
    Language
    en
    ISSN
    1433-8726
    ae974a485f413a2113503eed53cd6c53
    10.1007/s00345-018-2480-7
    Scopus Count
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