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    Short communication: management of patients with extensive-stage small-cell lung cancer treated with radiotherapy: a survey of practice.

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    Authors
    Haslett, Kate
    De Ruysscher, D
    Dziadziuszko, R
    Guckenberger, M
    Pechoux, C
    Nestle, U
    Slotman, B
    Faivre-Finn, Corinne
    Affiliation
    Manchester Cancer Research Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology Medicine & Health, University of Manchester, Manchester Academic Health Science Centre, The Christie NHS Foundation Trust, Manchester, UK
    Issue Date
    2018-08-30
    
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    Abstract
    The results of the randomized phase 3 CREST trial evaluating the use of thoracic radiotherapy for extensive-stage small-cell lung cancer (ES-SCLC) were published in the Lancet in 2015. The primary endpoint (10% overall survival difference at 1-year) was not achieved, but there was significant improvement in 2-year overall survival (13% vs 3%; p = 0.004) and low toxicity rates, suggesting thoracic radiotherapy should be considered for ES-SCLC patients who respond to chemotherapy. Questions have been raised as to whether these results will lead to a change in practice.
    Citation
    Short communication: management of patients with extensive-stage small-cell lung cancer treated with radiotherapy: a survey of practice. 2018, 17: 18-22 Cancer Treat Res Commun
    Journal
    Cancer Treatment and Research Communications
    URI
    http://hdl.handle.net/10541/621297
    DOI
    10.1016/j.ctarc.2018.08.004
    PubMed ID
    30196134
    Type
    Article
    Language
    en
    ISSN
    2468-2942
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.ctarc.2018.08.004
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