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    The potential value of MRI in external-beam radiotherapy for cervical cancer.

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    Authors
    Cree, Anthea
    Livsey, Jacqueline E
    Barraclough, Lisa H
    Dubec, Michael
    Hambrock, Thomas
    van Herk, Marcel
    Choudhury, Ananya
    McWilliam, Alan
    Affiliation
    Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M20 4BX,
    Issue Date
    2018-11
    
    Metadata
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    Abstract
    The reference standard treatment for cervical cancer is concurrent chemoradiotherapy followed by magnetic resonance imaging (MRI)-guided brachytherapy. Improvements in brachytherapy have increased local control rates, but late toxicity remains high with rates of 11% grade ≥3. The primary clinical target volume (CTV) for external-beam radiotherapy includes the cervix and uterus, which can show significant inter-fraction motion. This means that generous margins are required to cover the primary CTV, increasing the radiation dose to organs at risk and, therefore, toxicity. A number of image-guided radiotherapy techniques (IGRT) have been developed, but motion can be random and difficult to predict prior to treatment. In light of the development of integrated MRI linear accelerators, this review discusses the potential value of MRI in external-beam radiotherapy. Current solutions for managing pelvic organ motion are reviewed, including the potential for online adaptive radiotherapy. The impacts of the use of MRI in tumour delineation and in the delivery of stereotactic ablative body radiotherapy (SABR) are highlighted. The potential role and challenges of using multi parametric MRI to guide radiotherapy are also discussed.
    Citation
    The potential value of MRI in external-beam radiotherapy for cervical cancer. 2018, 30(11): 737-750 Clin Oncol (R Coll Radiol)
    Journal
    Clinical Oncology
    URI
    http://hdl.handle.net/10541/621296
    DOI
    10.1016/j.clon.2018.08.002
    PubMed ID
    30209010
    Type
    Article
    Language
    en
    ISSN
    1433-2981
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.clon.2018.08.002
    Scopus Count
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