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    Revert the SIRT: normalizing SIRT1 activity in myelodysplastic stem cells.

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    Authors
    Simeoni, Fabrizio
    Somervaille, Tim C P
    Affiliation
    Leukaemia Biology Laboratory, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, M20 4JG, UK
    Issue Date
    2018-09-06
    
    Metadata
    Show full item record
    Abstract
    Myelodysplastic syndromes are hematologic malignancies with few treatment options and a propensity to transform to acute myeloid leukemia. In this issue of Cell Stem Cell, Sun et al. (2018) report that low SIRT1 levels in myelodysplastic stem cells contribute to aberrant self-renewal through enabling hyperacetylation and reduced activity of TET2.
    Citation
    Revert the SIRT: normalizing SIRT1 activity in myelodysplastic stem cells. 2018, 23(3): 315-317 Cell Stem Cell
    Journal
    Cell Stem Cell
    URI
    http://hdl.handle.net/10541/621294
    DOI
    10.1016/j.stem.2018.08.003
    PubMed ID
    30193128
    Type
    Article
    Language
    en
    ISSN
    1875-9777
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.stem.2018.08.003
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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