Revert the SIRT: normalizing SIRT1 activity in myelodysplastic stem cells.
Affiliation
Leukaemia Biology Laboratory, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, M20 4JG, UKIssue Date
2018-09-06
Metadata
Show full item recordAbstract
Myelodysplastic syndromes are hematologic malignancies with few treatment options and a propensity to transform to acute myeloid leukemia. In this issue of Cell Stem Cell, Sun et al. (2018) report that low SIRT1 levels in myelodysplastic stem cells contribute to aberrant self-renewal through enabling hyperacetylation and reduced activity of TET2.Citation
Revert the SIRT: normalizing SIRT1 activity in myelodysplastic stem cells. 2018, 23(3): 315-317 Cell Stem CellJournal
Cell Stem CellDOI
10.1016/j.stem.2018.08.003PubMed ID
30193128Type
ArticleLanguage
enISSN
1875-9777ae974a485f413a2113503eed53cd6c53
10.1016/j.stem.2018.08.003