Revert the SIRT: normalizing SIRT1 activity in myelodysplastic stem cells.
AffiliationLeukaemia Biology Laboratory, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, M20 4JG, UK
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AbstractMyelodysplastic syndromes are hematologic malignancies with few treatment options and a propensity to transform to acute myeloid leukemia. In this issue of Cell Stem Cell, Sun et al. (2018) report that low SIRT1 levels in myelodysplastic stem cells contribute to aberrant self-renewal through enabling hyperacetylation and reduced activity of TET2.
CitationRevert the SIRT: normalizing SIRT1 activity in myelodysplastic stem cells. 2018, 23(3): 315-317 Cell Stem Cell
JournalCell Stem Cell