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    LSD1 inhibitors disrupt the GFI1 transcription repressor complex.

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    Authors
    Maiques-Diaz, Alba
    Lynch, James T
    Spencer, Gary J
    Somervaille, Tim C P
    Affiliation
    Leukaemia Biology Laboratory, Cancer Research UK Manchester Institute, The University of Manchester, Manchester
    Issue Date
    2018
    
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    Abstract
    Pharmacologic inhibition of KDM1A (Lysine Demethylase 1A) induces differentiation in certain subtypes of acute myeloid leukemia. Our recent studies reveal this is dependent upon drug-induced disruption of the GFI1 (Growth Factor Independent 1) transcription repressor complex, leading to activation of enhancers distributed close to genes controlling monocytic lineage differentiation.
    Citation
    LSD1 inhibitors disrupt the GFI1 transcription repressor complex. 2018, 5(4): e1481813 Mol Cell Oncol
    Journal
    Molecular & Cellular Oncology
    URI
    http://hdl.handle.net/10541/621290
    DOI
    10.1080/23723556.2018.1481813
    PubMed ID
    30250927
    Type
    Article
    Language
    en
    ISSN
    2372-3556
    ae974a485f413a2113503eed53cd6c53
    10.1080/23723556.2018.1481813
    Scopus Count
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    All Paterson Institute for Cancer Research

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