LSD1 inhibitors disrupt the GFI1 transcription repressor complex.
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LSD1 inhibitors disrupt the GFI1 ...
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Leukaemia Biology Laboratory, Cancer Research UK Manchester Institute, The University of Manchester, ManchesterIssue Date
2018
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Pharmacologic inhibition of KDM1A (Lysine Demethylase 1A) induces differentiation in certain subtypes of acute myeloid leukemia. Our recent studies reveal this is dependent upon drug-induced disruption of the GFI1 (Growth Factor Independent 1) transcription repressor complex, leading to activation of enhancers distributed close to genes controlling monocytic lineage differentiation.Citation
LSD1 inhibitors disrupt the GFI1 transcription repressor complex. 2018, 5(4): e1481813 Mol Cell OncolJournal
Molecular & Cellular OncologyDOI
10.1080/23723556.2018.1481813PubMed ID
30250927Type
ArticleLanguage
enISSN
2372-3556ae974a485f413a2113503eed53cd6c53
10.1080/23723556.2018.1481813