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    Imaging tumour hypoxia with oxygen-enhanced MRI and BOLD MRI.

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    Authors
    O'Connor, James P B
    Robinson, S
    Waterton, J
    Affiliation
    Division of Cancer Sciences, University of Manchester , Manchester , UK
    Issue Date
    2018-10-01
    
    Metadata
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    Abstract
    Hypoxia is known to be a poor prognostic indicator for nearly all solid tumours and also is predictive of treatment failure for radiotherapy, chemotherapy, surgery and targeted therapies. Imaging has potential to identify, spatially map and quantify tumour hypoxia prior to therapy, as well as track changes in hypoxia on treatment. At present no hypoxia imaging methods are available for routine clinical use. Research has largely focused on positron emission tomography (PET)-based techniques, but there is gathering evidence that MRI techniques may provide a practical and more readily translational alternative. In this review we focus on the potential for imaging hypoxia by measuring changes in longitudinal relaxation [R 1; termed oxygen-enhanced MRI or tumour oxygenation level dependent (TOLD) MRI] and effective transverse relaxation (R 2*; termed blood oxygenation level dependent (BOLD) MRI, induced by inhalation of either 100% oxygen or the radiosensitising hyperoxic gas carbogen. We explain the scientific principles behind oxygen-enhanced MRI and BOLD and discuss the significant studies and their limitations. All imaging biomarkers require rigorous validation in order to translate into clinical use and the steps required to further develop oxygen-enhanced MRI and BOLD MRI into decision-making tools are discussed.
    Citation
    Imaging tumour hypoxia with oxygen-enhanced MRI and BOLD MRI. 2018, 20180642 Br J Radiol
    Journal
    The British Journal of Radiology
    URI
    http://hdl.handle.net/10541/621282
    DOI
    10.1259/bjr.20180642
    PubMed ID
    30272998
    Type
    Article
    Language
    en
    ISSN
    1748-880X
    ae974a485f413a2113503eed53cd6c53
    10.1259/bjr.20180642
    Scopus Count
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