Investigation of myositis and scleroderma specific autoantibodies in patients with lung cancer.
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Department of Pharmacy and Pharmacology, University of Bath, Bath, UKIssue Date
2018-08-09
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The close temporal association between onset of some connective tissue diseases and cancer suggests a paraneoplastic association. Adult patients with scleroderma with anti-RNA polymerase III autoantibodies and adult patients with dermatomyositis with anti-transcriptional intermediary factor 1 (anti-TIF1) or anti-nuclear matrix protein 2 (anti-NXP2) autoantibodies have a significantly increased risk of developing cancer. Autoantibodies may serve as biomarkers for early detection of cancer and also could be relevant for prediction of responses to immune therapies. We aimed to test whether myositis and scleroderma specific or associated autoantibodies are detectable in individuals with lung cancer.Citation
Investigation of myositis and scleroderma specific autoantibodies in patients with lung cancer. 2018, 20(1): 176 Arthritis Res TherJournal
Arthritis Research & TherapyDOI
10.1186/s13075-018-1678-9PubMed ID
30092841Type
ArticleLanguage
enISSN
1478-6362ae974a485f413a2113503eed53cd6c53
10.1186/s13075-018-1678-9
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