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    Investigation of myositis and scleroderma specific autoantibodies in patients with lung cancer.

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    Authors
    Betteridge, Z
    Priest, L
    Cooper, R
    McHugh, N
    Blackhall, Fiona H
    Lamb, J
    Affiliation
    Department of Pharmacy and Pharmacology, University of Bath, Bath, UK
    Issue Date
    2018-08-09
    
    Metadata
    Show full item record
    Abstract
    The close temporal association between onset of some connective tissue diseases and cancer suggests a paraneoplastic association. Adult patients with scleroderma with anti-RNA polymerase III autoantibodies and adult patients with dermatomyositis with anti-transcriptional intermediary factor 1 (anti-TIF1) or anti-nuclear matrix protein 2 (anti-NXP2) autoantibodies have a significantly increased risk of developing cancer. Autoantibodies may serve as biomarkers for early detection of cancer and also could be relevant for prediction of responses to immune therapies. We aimed to test whether myositis and scleroderma specific or associated autoantibodies are detectable in individuals with lung cancer.
    Citation
    Investigation of myositis and scleroderma specific autoantibodies in patients with lung cancer. 2018, 20(1): 176 Arthritis Res Ther
    Journal
    Arthritis Research & Therapy
    URI
    http://hdl.handle.net/10541/621273
    DOI
    10.1186/s13075-018-1678-9
    PubMed ID
    30092841
    Type
    Article
    Language
    en
    ISSN
    1478-6362
    ae974a485f413a2113503eed53cd6c53
    10.1186/s13075-018-1678-9
    Scopus Count
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