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    Irreversible electroporation in pancreatic ductal adenocarcinoma: Is there a role in conjunction with conventional treatment?

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    Authors
    De Liguori Carino, N
    O'Reilly, D
    Siriwardena, A
    Valle, Juan W
    Radhakrishna, Ganesh
    Pihlak, Rille
    McNamara, Mairéad G
    Affiliation
    Regional Hepato-Pancreato-Biliary Unit, Manchester Royal Infirmary, Oxford Road, Manchester, M13 9WL, UK
    Issue Date
    2018-10
    
    Metadata
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    Abstract
    The incidence of pancreatic ductal adenocarcinoma (PDAC) is rapidly increasing. Up to 30% of patients present with locally advanced disease and therefore are not candidates for surgery. Locally advanced pancreatic cancer (LAPC) is an emerging entity lacking in level III evidence-based recommendations for its treatment. Currently, systemic chemotherapy is the main treatment for LAPC. However, due to lack of response or disease progression, downsizing of the tumour, making it resectable is successful in only a small proportion of patients. Radiotherapy is often advocated to improve local disease control if there is stability following chemotherapy. Recently, Irreversible Electroporation (IRE), a novel non-thermal ablation technique, has been proposed for the treatment of LAPC.
    Citation
    Irreversible electroporation in pancreatic ductal adenocarcinoma: Is there a role in conjunction with conventional treatment? 2018, 44(10): 1486-1493 Eur J Surg Oncol
    Journal
    European Journal of Surgical Oncology
    URI
    http://hdl.handle.net/10541/621264
    DOI
    10.1016/j.ejso.2018.07.047
    PubMed ID
    30146253
    Type
    Article
    Language
    en
    ISSN
    1532-2157
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.ejso.2018.07.047
    Scopus Count
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