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    PATRIOT: a phase I study to assess the tolerability, safety and biological effects of a specific ataxia telangiectasia and Rad3-related (ATR) inhibitor (AZD6738) as a single agent and in combination with palliative radiation therapy in patients with solid tumours.

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    Authors
    Dillon, M
    Boylan, Z
    Smith, D
    Guevara, J
    Mohammed, K
    Peckitt, C
    Saunders, Mark P
    Banerji, U
    Clack, G
    Smith, S
    Spicer, J
    Forster, M
    Harrington, K
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    Affiliation
    The Institute of Cancer Research, London, UKThe Royal Marsden NHS Foundation Trust, London, UK
    Issue Date
    2018-08
    
    Metadata
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    Abstract
    PATRIOT is a phase I study of the ATR inhibitor, AZD6738, as monotherapy, and in combination with palliative radiotherapy. Here, we describe the protocol for this study, which opened in 2014 and is currently recruiting and comprises dose escalation of both drug and radiotherapy, and expansion cohorts.
    Citation
    PATRIOT: a phase I study to assess the tolerability, safety and biological effects of a specific ataxia telangiectasia and Rad3-related (ATR) inhibitor (AZD6738) as a single agent and in combination with palliative radiation therapy in patients with solid tumours. 2018, 12: 16-20 Clin Transl Radiat Oncol
    Journal
    Clinical and Translational Radiation Oncology
    URI
    http://hdl.handle.net/10541/621205
    DOI
    10.1016/j.ctro.2018.06.001
    PubMed ID
    30073210
    Type
    Article
    Language
    en
    ISSN
    2405-6308
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.ctro.2018.06.001
    Scopus Count
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