The influence of radiation in the context of developing combination immunotherapies in cancer.
AffiliationTargeted Therapy Group, Division of Cancer Sciences, Manchester Cancer Research Centre, Christie Hospital, Manchester Academic Health Sciences Centre, National Institute of Health Research Biomedical
MetadataShow full item record
AbstractIn addition to tumouricidal activity, radiotherapy is now recognized to display potent immunostimulatory properties that can contribute to the generation of anti-cancer immune responses. Treatment with radiation can induce a variety of pro-immunogenic and phenotypic changes in malignant cells, and recalibrate the immune contexture of the tumour microenvironment, leading to enhanced activation of the innate immune system, and priming of tumour-specific T-cell immunity. The immune-dependent effects of radiotherapy provide a sound rationale for the development of combination strategies, whereby the immunomodulatory properties of radiation can be exploited to augment the activity of immunotherapeutic agents. Encouraged by the recent success of breakthrough therapies such as immune checkpoint blockade, and a wealth of experimental data demonstrating the efficacy of radiotherapy and immunotherapy combinations, the clinical potential of this approach is now being explored in numerous trials. Successful translation will require careful consideration of the most suitable dose and fractionation of radiation, choice of immunotherapy and optimal sequencing and scheduling regimen. Immunological control of cancer is now becoming a clinical reality. There is considerable optimism that the development of effective radiotherapy and immunotherapy combinations with the capacity to induce durable, systemic immunity will further enhance patient outcome and transform the future management of cancer.
CitationThe influence of radiation in the context of developing combination immunotherapies in cancer. 2017, 5(6): 115-122 Ther Adv Vaccines Immunother
JournalTherapeutic Advances in Vaccines and Immunotherapy
- Reprogramming the tumour microenvironment by radiotherapy: implications for radiotherapy and immunotherapy combinations.
- Authors: Colton M, Cheadle EJ, Honeychurch J, Illidge TM
- Issue date: 2020 Nov 4
- Immune checkpoint inhibitors with radiotherapy and locoregional treatment: synergism and potential clinical implications.
- Authors: Esposito A, Criscitiello C, Curigliano G
- Issue date: 2015 Nov
- Combined Radiation Therapy and Immune Checkpoint Blockade Therapy for Breast Cancer.
- Authors: Hu ZI, Ho AY, McArthur HL
- Issue date: 2017 Sep 1
- Future perspectives in melanoma research : Meeting report from the "Melanoma Bridge". Napoli, December 1st-4th 2015.
- Authors: Ascierto PA, Agarwala S, Botti G, Cesano A, Ciliberto G, Davies MA, Demaria S, Dummer R, Eggermont AM, Ferrone S, Fu YX, Gajewski TF, Garbe C, Huber V, Khleif S, Krauthammer M, Lo RS, Masucci G, Palmieri G, Postow M, Puzanov I, Silk A, Spranger S, Stroncek DF, Tarhini A, Taube JM, Testori A, Wang E, Wargo JA, Yee C, Zarour H, Zitvogel L, Fox BA, Mozzillo N, Marincola FM, Thurin M
- Issue date: 2016 Nov 15
- Combining Immunotherapy and Radiotherapy for Cancer Treatment: Current Challenges and Future Directions.
- Authors: Wang Y, Deng W, Li N, Neri S, Sharma A, Jiang W, Lin SH
- Issue date: 2018