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    DNA methylation and repressive histones in the promoters of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, PD-L1, and galectin-9 genes in human colorectal cancer.

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    Authors
    Sasidharan, Nair V
    Toor, S
    Taha, R
    Shaath, H
    Elkord, Eyad
    Affiliation
    Cancer Research Center, Qatar Biomedical Research Institute, College of Science and Engineering, Hamad Bin Khalifa University, Qatar Foundation, P.O. Box 5825, Doha, Qatar
    Issue Date
    2018-08-06
    
    Metadata
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    Abstract
    Colorectal cancer (CRC) is the third most commonly diagnosed human malignancy worldwide. Upregulation of inhibitory immune checkpoints by tumor-infiltrating immune cells (TIICs) or their ligands by tumor cells leads to tumor evasion from host immunosurveillance. Changes in DNA methylation pattern and enrichment of methylated histone marks in the promoter regions could be major contributors to the upregulation of immune checkpoints (ICs) in the tumor microenvironment (TME).
    Citation
    DNA methylation and repressive histones in the promoters of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, PD-L1, and galectin-9 genes in human colorectal cancer. 2018, 10(1): 104 Clin Epigenetics
    Journal
    Clinical Epigenetics
    URI
    http://hdl.handle.net/10541/621170
    DOI
    10.1186/s13148-018-0539-3
    PubMed ID
    30081950
    Type
    Article
    Language
    en
    ISSN
    1868-7083
    ae974a485f413a2113503eed53cd6c53
    10.1186/s13148-018-0539-3
    Scopus Count
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    All Paterson Institute for Cancer Research

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