DNA methylation and repressive histones in the promoters of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, PD-L1, and galectin-9 genes in human colorectal cancer.
Affiliation
Cancer Research Center, Qatar Biomedical Research Institute, College of Science and Engineering, Hamad Bin Khalifa University, Qatar Foundation, P.O. Box 5825, Doha, QatarIssue Date
2018-08-06
Metadata
Show full item recordAbstract
Colorectal cancer (CRC) is the third most commonly diagnosed human malignancy worldwide. Upregulation of inhibitory immune checkpoints by tumor-infiltrating immune cells (TIICs) or their ligands by tumor cells leads to tumor evasion from host immunosurveillance. Changes in DNA methylation pattern and enrichment of methylated histone marks in the promoter regions could be major contributors to the upregulation of immune checkpoints (ICs) in the tumor microenvironment (TME).Citation
DNA methylation and repressive histones in the promoters of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, PD-L1, and galectin-9 genes in human colorectal cancer. 2018, 10(1): 104 Clin EpigeneticsJournal
Clinical EpigeneticsDOI
10.1186/s13148-018-0539-3PubMed ID
30081950Type
ArticleLanguage
enISSN
1868-7083ae974a485f413a2113503eed53cd6c53
10.1186/s13148-018-0539-3
Scopus Count
Collections
Related articles
- DNA methylation and repressive H3K9 and H3K27 trimethylation in the promoter regions of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, and PD-L1 genes in human primary breast cancer.
- Authors: Sasidharan Nair V, El Salhat H, Taha RZ, John A, Ali BR, Elkord E
- Issue date: 2018
- DNA methylation of immune checkpoints in the peripheral blood of breast and colorectal cancer patients.
- Authors: Elashi AA, Sasidharan Nair V, Taha RZ, Shaath H, Elkord E
- Issue date: 2019
- CTLA4 , PD-1 , PD-L1 , PD-L2 , TIM-3 , TIGIT , and LAG3 DNA Methylation Is Associated With BAP1 -Aberrancy, Transcriptional Activity, and Overall Survival in Uveal Melanoma.
- Authors: de Vos L, Carrillo Cano TM, Zarbl R, Klümper N, Ralser DJ, Franzen A, Herr E, Gabrielpillai J, Vogt TJ, Dietrich J, Strieth S, Landsberg J, Dietrich D
- Issue date: 2022 Sep 1
- Epigenetic regulation of immune checkpoints and T cell exhaustion markers in tumor-infiltrating T cells of colorectal cancer patients.
- Authors: Sasidharan Nair V, Saleh R, Toor SM, Taha RZ, Ahmed AA, Kurer MA, Murshed K, Abu Nada M, Elkord E
- Issue date: 2020 Nov
- Genetic signature of CTLA-4, BTLA, TIM-3 and LAG-3 molecular expression in colorectal cancer patients: Implications in diagnosis and survival outcomes.
- Authors: Kamal AM, Wasfey EF, Elghamry WR, Sabry OM, Elghobary HA, Radwan SM
- Issue date: 2021 Oct