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dc.contributor.authorSasidharan Nair, V
dc.contributor.authorEl Salhat, H
dc.contributor.authorTaha, R
dc.contributor.authorJohn, A
dc.contributor.authorAli, B
dc.contributor.authorElkord, Eyad
dc.date.accessioned2018-07-29T12:42:04Z
dc.date.available2018-07-29T12:42:04Z
dc.date.issued2018
dc.identifier.citationDNA methylation and repressive H3K9 and H3K27 trimethylation in the promoter regions of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, and PD-L1 genes in human primary breast cancer. 2018, 10: 78 Clin Epigeneticsen
dc.identifier.issn1868-7083
dc.identifier.pmid29983831
dc.identifier.doi10.1186/s13148-018-0512-1
dc.identifier.urihttp://hdl.handle.net/10541/621154
dc.description.abstractHigh expression of immune checkpoints in tumor microenvironment plays significant roles in inhibiting anti-tumor immunity, which is associated with poor prognosis and cancer progression. Major epigenetic modifications in both DNA and histone could be involved in upregulation of immune checkpoints in cancer.
dc.language.isoenen
dc.rightsArchived with thanks to Clinical epigeneticsen
dc.titleDNA methylation and repressive H3K9 and H3K27 trimethylation in the promoter regions of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, and PD-L1 genes in human primary breast cancer.en
dc.typeArticleen
dc.contributor.departmentCancer Research Center, Qatar Biomedical Research Institute, College of Science and Engineering, Hamad Bin Khalifa University, Qatar Foundation, Doha, Qatar.en
dc.identifier.journalClinical Epigeneticsen
refterms.dateFOA2018-12-17T15:29:10Z
html.description.abstractHigh expression of immune checkpoints in tumor microenvironment plays significant roles in inhibiting anti-tumor immunity, which is associated with poor prognosis and cancer progression. Major epigenetic modifications in both DNA and histone could be involved in upregulation of immune checkpoints in cancer.


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